DOE 1993 Program Report: Abstract TOC

U.S. Department of Energy

Human Genome 1993 Program Report: Abstract Table of Contents

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Date Published: March 1994

For a printed copy of this document, contact
Human Genome Management Information System
Oak Ridge National Laboratory
1060 Commerce Park, MS 6480
Oak Ridge, TN 37830
423-576-6669, Fax: 423-574-9888
Internet: bkq@ornl.gov

Abstracts of DOE-Funded Research

The abstracts in this document were contributed by DOE Human Genome Program grantees and contractors. Names of principal investigators are in bold print. Telephone and telefax numbers and electronic mail address are for the first investigator named unless noted otherwise. Descriptions of the research categories follow, and a table of contents of categorized projects with their principal investigators begins on the next page. An index of all investigators named in the abstracts is given at the end of this report.

Descriptions of Research Category Listings

Projects New in FY 1993: Projects that were reviewed by the fall 1992 panel and funded in the genome program are represented by complete abstracts (including investigators, affiliations, and contact information).

Projects Renewed in FY 1993: FY 1992 final-year projects that were renewed for FY 1993 are also represented by complete abstracts.

Projects Continuing into FY 1993: Projects for which funding was initiated prior to FY 1993 and continues in FY 1993 are represented by titles, investigators, affiliations, and contact information. Complete abstracts are in the DOE Human Genome 1991-92 Program Report (please consult its index).

Projects Completed in FY 1993: Titles of projects that terminated in the fall of 1992 are listed with their investigators.

Project Categories and Principal Investigators*

*Thirteen new projects (designated by an asterisk) are funded through small emergency grants to Russian scientists following December 1992 site reviews by David Galas (formerly OHER), Raymond Gesteland (University of Utah), and Elbert Branscomb (LLNL).

Principal investigators of the research projects described by the abstracts in this section are listed here under their respective subject categories.

RESOURCE DEVELOPMENT

New Projects

*Inga P. Arman *Maxim L. Filipenko and Elena I. Yantsen Jeff Gingrich and Anthony Carrano *A. D. Mirzabekov *Olga Igorevna Podgornaya *O. L. Polanovsky Lisa Stubbs and Elbert Branscomb *V. Vlassov

Projects Continuing into FY 1993

Raghbir S. Athwal E. Morton Bradbury and Joe M. Gatewood Charles R. Cantor Jan-Fang Cheng Larry L. Deaven Larry L. Deaven Jeff Gingrich Joe Gray Cynthia L. Jackson Fa-Ten Kao Julie R. Korenberg Michael J. Lane, Peter Hahn, and John Hozier Gregory G. Lennon and Anthony V. Carrano Christopher H. Martin and Michael J. Palazzolo MaryKay McCormick, Larry Deaven, and Robert Moyzis Donald T. Moir Robert K. Moyzis David L. Nelson William C. Nierman and Donna R. Maglott Mihael H. Polymeropoulos Eugene Rinchik and Richard Woychik Michael J. Siciliano James M. Sikela Marcelo Bento Soares Jean-Michel H. Vos Geoffrey Wahl Richard Woychik and Eugene Rinchik

PHYSICAL AND GENETIC MAPPING

New Projects

Alla Lishanski and Jasper Rine Maynard Olson Elaine A. Ostrander Jasper Rine Barbara Trask and Ger van den Engh *Nick K. Yankovsky

Projects Continuing into FY 1993

Mark Batzer Brigette Brandriff and Anthony Carrano Anthony V. Carrano C. Thomas Caskey and David L. Nelson Jan-Fang Cheng Glen A. Evans Christopher H. Martin and Michael J. Palazzolo Harvey W. Mohrenweiser R. K. Moyzis Anne S. Olsen Melvin I. Simon Cassandra L. Smith Lisa J. Stubbs and Eugene Rinchik Grant R. Sutherland

MAPPING INSTRUMENTATION

New Projects

*Alexandre S. Boitsov *Andrei I. Poletaev Miguel Salmeron Ger van den Engh and Barbara Trask

Projects Continuing into FY 1993

Tony J. Beugelsdijk James H. Jett, John C. Martin, and Mark E. Wilder Barry L. Karger William F. Kolbe, Joseph E. Katz, and Joseph M. Jaklevic Patricia A. Medvick Donald C. Uber

SEQUENCING TECHNOLOGIES

New Projects

Radomir Crkvenjakov Radoje Drmanac Andrei Mirzabekov *Oleg I. Serpinsky F. William Studier and John J. Dunn

Renewed Projects

Edward S. Yeung

Projects Continuing into FY 1993

Thomas M. Brennan Gilbert M. Brown C. H. Winston Chen, Marvin G. Payne, and K. Bruce Jacobson George Church Radomir Crkvenjakov and Radoje Drmanac Jack B. Davidson M. Bonner Denton and Richard Keller Norman J. Dovichi John J. Dunn and F. William Studier Thomas L. Ferrell, Robert J. Warmack, and David P. Allison Robert S. Foote Raymond F. Gesteland Leroy E. Hood K. Bruce Jacobson Joseph M. Jaklevic and W. Henry Benner James H. Jett, Richard A. Keller, John C. Martin, and E. Brooks Shera Christopher H. Martin and Michael J. Palazzolo Richard A. Mathies and Alexander N. Glazer Michael C. Pirrung Charles C. Richardson Arthur D. Riggs Lloyd M. Smith Lloyd M. Smith and Brian Chait Lloyd M. Smith and David Mead Richard D. Smith F. William Studier and John J. Dunn Peter Williams and Neal Woodbury

INFORMATICS: Part 1

New Projects

*Alexander B. Chetverin, A. R. Rubinov, and M. S. Gelfand Gary A. Churchill Michael J. Cinkosky Radomir Crkvenjakov Radoje Drmanac *Nikolay A. Kolchanov Suzanna Lewis, John McCarthy, and Edward Theil Hwa A. Lim Ross Overbeek and Patrick Gillevet Stewart Scherer

INFORMATICS: Part 2
*Evgenij E. Selkov Gary D. Stormo Edward H. Theil Eugene Veklerov and Christopher Martin Manfred D. Zorn Manfred D. Zorn Renewed Projects

Eugene Lawler and Daniel Gusfield David B. Searls

Projects Continuing into FY 1993

Elbert Branscomb Richard J. Douthart Vance Faber and David Torney James W. Fickett Christopher A. Fields and Carol A. Soderlund Tim Hunkapiller Jerzy Jurka David Kingsbury Charles B. Lawrence and Eugene W. Myers Victor M. Markowitz Victor M. Markowitz Thomas G. Marr and Andrew Reiner Jude W. Shavlik and Michiel O. Noordewier David Torney Edward Uberbacher and Richard Mural Edward Uberbacher, Richard Mural, and Reinhold Mann

ETHICAL, LEGAL, AND SOCIAL ISSUES

New Projects

George J. Annas Diane Baker and Paula Gregory Alex Capron and Bartha Knoppers Charles C. Carlson Joseph D. McInerney Declan Murphy and Claudette Cyr Friedman Philip R. Reilly Alan F. Westin Michael S. Yesley Franklin M. Zweig

1993 Conferences

Thomas G. Field Ed Golub Sheila Jasanoff

Projects Continuing into FY 1993

Paula Apsell and Graham Chedd Ruth E. Bulger Debra L. Collins, R. Neil Schimke, and Linda Segebrecht Troy Duster Marvin Natowicz George Page and Stefan Moore Ralph W. Trottier and Lee A. Crandall

INFRASTRUCTURE

Renewed Projects

Peter Arzberger

Projects Continuing into FY 1993

Linda Holmes and Alfred Wohlpart Amanda Lumley and James Wright Betty K. Mansfield and John S. Wassom Sylvia Spengler Michael S. Yesley

Small Business Innovation Research (SBIR)

SBIR Phase I

Projects New in FY 1993

Douglas J. Eadline Cathy D. Newman Peter Richterich David S. Soane

Projects Continuing into FY 1993

Wayne Dettloff and Holt Anderson John R. Hartman Michael T. MacDonell and Darlene B. Roszak Douglas J. McAllister

SBIR Phase II

Projects Continuing into FY 1993

Heinrich F. Arlinghaus George Golumbeski John R. Hartman

SBIR Phases I and II

Projects Continuing into FY 1993

David L. Barker and Jay Flatley Stephen P. A. Fodor Chris S. Martin, Corinne E. M. Oleson, and Irena Bronstein

COMPLETED PROJECTS

Projects in this category are either completed or no longer receiving support through the DOE Human Genome Program.

Resource Development

Venigalla B. Rao Betsy M. Sutherland J. Craig Venter Philip A. Youdarian

Physical and Genetic Mapping

Jeffrey C. Gingrich

Mapping Instrumentation

J. Calvin Giddings James F. Hainfeld Joseph Jaklevic Leonard Lerman Edward S. Yeung

Sequencing Technologies

Joseph M. Jaklevic and W. F. Kolbe Raoul Kopelman, John Langmore, and Bradford Orr Linda D. Strausbaugh and Claire M. Berg

Informatics

James Cassatt Suzanna Lewis and Frank Olken Suzanna Lewis, Manfred Zorn, and John McCarthy Frank Olken Manfred D. Zorn

Ethical, Legal, and Social Issues

C. Thomas Caskey Frank Grad Joseph D. McInerney Philip Reilly Jan Witkowski

Infrastucture

Charles R. Cantor

SBIR

Phase I

Heinrich F. Arlinghaus Frederic R. Furuya Gerald D. Hurst

Phase II

Norman G. Anderson

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