DOE Human Genome Program Contractor-Grantee Workshop VIII
February 27-March 2, 2000  Santa Fe, NM

95. The I.M.A.G.E. Consortium: Progress Toward a Complete Set of Human Genes

Christa Prange, Peg Folta, Tim Harsch, Genevieve Johnson, Tom Kuczmarksi, Bernadette Lato, Leeanne Mila, David Nelson, and Anthony Carrano

Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, CA 94550

prange1@llnl.gov

The I.M.A.G.E. Consortium is the largest publicly available collection of cDNAs, containing approximately three million clones. cDNAs are currently derived from five different species, with an emphasis on sampling from both normal and abnormal human and mouse tissue types at a variety of developmental stages. As a collaborative effort between the National Cancer Institute (NCI) and various academic groups, the Cancer Genome Anatomy Project employs EST sequence data to characterize normal, pre-cancerous, and cancerous cell types. We have also recently begun arraying cDNAs from full-length enriched libraries as part of the Mammalian Gene Collection, a collaborative effort between the I.M.A.G.E. Consortium, the National Institutes of Health, the National Center for Biotechnology Information, and many academic groups.

Another goal of the I.M.A.G.E. Consortium is to provide web-based software to aid in the analysis of clones derived from I.M.A.G.E. libraries. Re-arrayed sets of clones representing specific target genes will be chosen based on this clustering analysis, and made available for use by the community.

Further information about the I.M.A.G.E. Consortium is available by email (info@image.llnl.gov) or through the WWW.

This work was performed under the auspices of the U.S. Department of Energy, Office of Health and Environmental Research (OHER) by Lawrence Livermore National Laboratory under contract no. W-7405-Eng-48.