DOE Human Genome Program Contractor-Grantee Workshop VIII
February 27-March 2, 2000  Santa Fe, NM

157. Our Vision for the New Protein Data Bank

Helen Berman¹, John Westbrook¹, Kyle Burkhardt¹, Zukang Feng1 Shri Jain¹, Rachel Kramer¹, Bohdan Schneider¹, Christine Zardecki¹, Peter Arzberger², Phil Bourne², John Badger², Helge Weissig², Gary L. Gilliland³, Phoebe Fagan³, Diane Hancock³, Narmada Thanki³, and Gregory B. Vasquez³

¹Rutgers University, Piscataway, NJ, USA, ²San Diego Supercomputer Center, University of California, San Diego, CA, USA, and ³National Institute of Standards And Technology, Gaithersburg, MD, USA

gregory.vasquez@nist.gov

On October 1, 1998, the Research Collaboratory for Structural Bioinformatics (RCSB) became responsible for the management of the Protein Data Bank (PDB). The RCSB members are Rutgers, the State University of New Jersey, the San Diego Supercomputer Center of the University of California, San Diego, and the National Institute of Standards and Technology. The vision of the RCSB (http://www.rcsb.org/pdb/) is to enable new science by providing accurate, consistent, and well-annotated structure data via the application and development of modern information technology. Data is deposited and processed by the RCSB using an integrated dataprocessing system called ADIT (the AutoDep Input Tool). Adit provides rapid and reliable data processing, and is also being used to revisit all existing structures in the PDB to create a more uniform archive. The RCSB has also developed a query and reporting interface to search across the PDB archive. Searches and reports can be generated for single or multiple structures. As the quality of the data improves, the reliability of the query results will improve. These systems and plans for extending the capabilities of the new PDB will be described.

This project is funded by the National Science Foundation, the Department of Energy, and two units of the National Institutes of Health: the National Institute of General Medical Sciences and the National Library of Medicine.