Function and cDNA Resources Section 

DOE Human Genome Program Contractor-Grantee Workshop VIII
February 27-March 2, 2000  Santa Fe, NM

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149. Probe design on genomic level for DNA oligo microarrays

Li, F. and Stormo, G.D.

Dept of Genetics, Washington University Medical School St. Louis, MO 63110

stormo@genetics.wustl.edu

We have designed a program to predict optimal oligo-probes for each gene in an entire genome. Criteria used for optimality are maximizing the minimum number of mismatches to every other gene, finding appropriate T_m for the correct gene match and maximizing the reduction in T_m for the mismatched genes. We have used the probe to predict a set of optimal probes for each of several model systems that have complete genome sequences and put them in a publicly available database: ural.wustl.edu/~lif/probe.pl

The program is also available from the authors for use on any other sequence sets.

 

The online presentation of this publication is a special feature of the Human Genome Project Information Web site.