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Peer-Reviewed Journal Articles, 2004

Knapp, F. F., Jr., Turner, J. H., Jeong, J.-M. and Padhy, A. K. “Issues Associated with the Use of the Tungsten-188/Rhenium-188 Generator and Concentration System and Preparation of Re-188-HDD,” World Journal of Nuclear Medicine, 3, 137-143 (2004).

Reynen, K., Kockeritz, U., Kropp, J., Wunderlich, G., Knapp, F. F., Schmeisser, A, and Strasse, R. H. ”Intracoronary Radiotherapy with a Rhenium-188 Liquid-Filled PTCA Balloon System in In-Stent Restenosis: Acute and Long-Term Angiographic Results, as well as 1 Year Clinical Follow-up,” Internat. J. Card., 95, 29-34 (2004).

Book Chapters and Meeting Proceedings and Special Publications Describing ORNL Technology

Knapp, F. F., Jr., Cosgrove, J. M. and Porter, C. E. “The Tungsten-188/Rhenium-188 Generator – An Attractive Cost Effective Source of Rhenium-188 for Clinical Use,” Technical Document (TECDOC) # , Research Coordination Meeting (RCM) on Radionuclide Generators, International Atomic Energy Agency (IAEA), Vienna, Austria, October 4-8, 2004.

Bax, J. J., Knapp, F. F., Jr. and Visser, F. C. “Single-Photon Imaging of Myocardial Metabolism: Role of Iodine-123 Fatty Acids and Fluorine-18 Deoxyglucose,” In, Nuclear Medicine in Clinical Diagnosis and Treatment; P. J. Ell and S. S. Gambhir, Editors; 3rd Edition, Churchill Livingston, Edinburgh, 2004 (ISBN 0 443 07312 0).

Patents

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. ”High Specific Activity Platinum-195m,“ U. S. Patent No. 6,804,319, Issued October 12, 2004.

Beets, A. L., Du, M., Mirzadeh, S. and Knapp, F. F., Jr. “Method for Preparation of High Specific Activity Reactor-Produced Lutetium-177,” U.S. Patent No. 6,716,353, Issued April 5, 2004.

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. “New Method for Preparation of High Specific Activity Platinum-195m for Medical Therapy,” U. S. Patent No. 6,751,280, Issued June 15, 2004.

Meeting Presentations and Published Abstracts

Chen, L., Wang, W. D., Chen, Y. C. and Knapp, F. F. “Generator Elution and Concentration of Rhenium-188,“ 51st Annual Meeting, Society of Nuclear Medicine, J. Nucl. Med., 44, Abstract # 1517 (2004).

Knapp, F. F., Jr. “Rhenium-188 and Lutetium-177– Reactor Production and Development and Applications of Therapeutic Radiopharmaceuticals,” Invited Lecture, 6th International Radiopharmaceutical Therapy Colloquium, Pre-Congress Meeting, held in association with, 8th Congress of the Asia and Oceania Federation of Nuclear Medicine and Biology, Beijing, China, October 9, 2004.

Knapp, F. F., Jr. “Rhenium-188 – A Generator-Derived Radioisotope with Broad Therapeutic Applications in Nuclear Medicine and Oncology,” Invited Lecture, Research Coordination Meeting on Radionuclide Generator Technologies for Therapeutic Radionuclides, International Atomic Energy Agency (IAEA), Vienna, Austria, October 4-7, 2004.

Knapp, F. F., Jr. , “Rhenium-188 Agents for Liver Cancer Therapy – Current Status and Future Perspectives,” Inaugural Clinical Investigators Meeting for the Proposed European/Asia and Oceania Phase I/II Study on Rhenium-188-DEDC Lipiodol Intrahepatic Arterial Therapy of Hepatocellular Carcinoma, Ferrara, Italy, September 9, 2004; Pre-Congress Symposium of the Annual European Association of Nuclear Medicine Congress, Helsinki, Finland, Sept. 4-8, 2004.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du, M. and Garland, M. ”Reactor Production of High Specific Activity Lutetium-177,“ Eur. J. Nucl. Med., 31, Suppl. 2, S387 (2004) (Poster # 455).

Knapp, F. F., Jr., “Rhenium-188 for Cancer Therapy – A Reactor-Produced Radioisotope with Broad Applications in Nuclear Medicine and Oncology,” NNSA/NA-243 Sister Laboratory Expert Mission, Institute for Nuclear Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr., “Reactor-Produced Therapeutic Radioisotopes,” NNSA/NA-243 Sister Laboratory Expert Mission, Institute for Nuclear Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr. “Molybdenum-99 – Advantages for Direct Production from Mo-98 Versus Fission Production,” NNSA/NA-243 Sister Laboratory Expert Mission, Institute for Nuclear Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr., Mirzadeh, S., Beets, a. L., Du. M. and Garland, M. “Reactor Production of High Specific Activity Lutetium-177,“ Eur. J. Nucl. Med., 31 (Suppl. 2), S387 (2004).

Knapp, F. F., Jr. “New Developments with Unsealed Sources for Targeted Radiotherapy,” Invited Lecture, 51st Bad Gastein Lecture, Bad Gastein, Austria, January 14-17, 2004.

Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser, A., Knapp, F. F. and Strasser, R. R. “Intracoronary Radiotherapy with Re-188 Liquid-Filled Balloon: The Dresden Prospective, Randomized, Placebo-Controlled, Double-Blind, In Stent Restenosis Trial (DRAIN),“ 51st Annual Meeting, Society of Nuclear Medicine, J. Nucl. Med., 44, Abstract # 802 (2004).

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