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Peer-Reviewed Journal Articles, 2003

Garland, M. A., Mirzadeh, S., Alexander, C. W., Hirtz, G. J., Hobbs, R. W. and Knapp, F. F., Jr. “Flux Characterization of the Peripheral Target Positions in the High Flux Isotope Reactor,” Appl. Radiat. Isot., 59, 63-72 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR),“ J. Label Cmpds. Radiopharm., 46 (Suppl. 1), S320(2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Garland, M. ”Production of Medical Radioisotopes in the ORNL High Flux Isotope Reactor,“ Transactions, American Nuclear Society, 89, 765-766 (2003).

Knapp, F. F., Jr. and Kropp, J. “The 11th Mediterranean Meeting on Nuclear Medicine and Radiopharmaceuticals,“ Eur. J. Nucl. Med., 30, 1701-1702 (2003).

Haverlock, T. J., Mirzadeh, S. and Moyer, B. A. “Selectivity of Calix[4]arene-bis(benzocrown-6) in the Complexation and Transport of Francium Ion,” J. Amer. Chem. Soc., 125, 1126-1127 (2003).

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Franke, W.-G. “Radiation Dosimetry of Rhenium-188-HEDP in Human Prostate Cancer Skeletal Metastases,” J. Nucl. Med., 44, 953-960 (2003).

Palmedo, H., Manka-Waluch, A., Albers, P., Schmidt, W., Guhlke, S., Reinhardt, M., Ezziddin, S., Joe, A., Roedel, R., Fimmers, H., Knapp, F. F., Jr. and Biersack, H.-J. “Repeated Bone Targeted Therapy for Hormone-Refractory Prostate Carcinoma: Randomized Phase II Trial with the New, High-Energy Radiopharmaceutical Rhenium-188-HEDP,” J. Clin. Oncol., 21, 2869-2875 (2003).

Ponsard, B., Hiltunen, J., Vera-Ruiz, H., Beets, A. L., Mirzadeh, S. and Knapp, F. F., Jr. “The Tungsten-188/Rhenium-188 Generator: Effective Coordination of Tungsten-188 Production Between the HFIR and BR2 Reactors,” J. Radioanalyt. Nucl. Chem., 257, 169-174 (2003).

Sloof, G. W., Knapp, F. F., Jr., van Lingen, A., Eersels, J., Poldermans, D. and Bax, J. J. “Nuclear Imaging Is More Sensitive For the Detection of Viable Myocardium Than Dobutamine Echocardiography,” Nuclear Med. Commun., 24, 357-381 (2003).

Verberne, H. J., Sloof, G. W., Beets, A. L., Murphy, A. M., van Eck-Smit, N. L. F. and Knapp, F. F., Jr. “Free Fatty Acid and Glucose Uptake in a Transgenic Mouse Model of Stunned Myocardium,” Eur. J. Nucl. Med., 30, 431-439 (2003).

Granadas, O. H., Stevens, S. L., Donnell, R. L., Costanza, M. J., Spencer R. H., Knapp, F. F., Jr., Shoieb, A. M., Brown, K. J., Reddick, T. T., Freeman, M. B. and Goldman, M. H. "Effect of Intravascular Radiation on the Distribution of Macrophages, Platelet-Derived Growth Factor and Transforming Growth Factor in the Swine Iliac Artery," Annals Vasc. Surg., in press.

Knapp, F. F., Jr., “Radionuclide Generators: Their Continuing Important Role to Provide Radioisotopes for Diagnosis and Therapy,” J. Nucl. Med., Invited Continuing Education Review, in preparation.

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Franke, W.-G. "Radiation Dosimetry of Rhenium-188-HEDP in the Therapy of Painful Bone Metastases," J. Nucl. Med., in press.

Zetting, G., Dobrozemsky, G., Kirisits, C., Wexberg, P., Cejna, M., Mitterhauser, Knapp, F. F., Jr. and Dudczak, R. "Endovascular Radiation with Liquid-Filled Balloons - The Impact of Reused Balloon Catheters on the Projected Dose," Appl. Radiat. Isot., submitted

Book Chapters and Meeting Proceedings and Special Publications Describing ORNL Technology

Iyer, S. R. and Knapp, F. F., Jr. Editors, for, “Manual for Reactor Production of Radioisotopes,” International Atomic Energy Agency (IAEA), TECDOC-1340; Vienna, Austria, January 2003. (ISBN-92-0-101103-2).

Knapp, F. F., Jr. “Applications of Rhenium-188-Labeled Agents in Oncology,” In, Proceedings, the 11th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 147-156 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Kropp, J., Pinkert, J., Wunderlich, G., and Knapp, F. F., Jr., “Radiohchemistry, Evaluation and First Clinical Results in the Treatment of Oncologic Diseases with Rhenium-188-Labeled Microspheres,” In, Proceedings, the 11th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 157-166 (2003).

Mausner, L. F. and Mirzadeh, S. “Reactor Production of Radionuclides,” In, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, M. J. Welch and C. Redvanly, Editors; John Wiley and Sons, Ltd., in press.

Mirzadeh, S., Mausner, L. F. and Garland, M. “Reactor-Produced Medical Radioisotopes,“ In, Handbook of Nuclear Chemistry, Volume 4, Chapter 3, pp. 1-46; A. Vertes, N. S. Klencsar, Editors; Kluwer Academic Publishers, Amsterdam (2003).

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Kotzerke, J. ”Rhenium-188 HEDP Dosimetry in Bone Pain Induced by Prostate Cancer,” In, Proceedings, the 11th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 69-82 (2003).

Ponsard, B., Mirzadeh, S. and Knapp, F. F., Jr. “Production of Tungsten-188 in the BR2 Reactor in Collaboration with ORNL,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Roesch, F. and Knapp, F. F., Jr. “Radionuclide Generators,“ In, Handbook of Nuclear Chemistry, Volume 4, Chapter 3, pp. 81-118; A. Vertes, N. S. Klencsar, Editors; Kluwer Academic Publishers, Amsterdam (2003).

Meeting Presentations and Published Abstracts

Boll, R. A., Malkemus, D. W. and Mirzadeh, S. “Production of Actinium-225 for Alpha Particle Mediated Radiotherapy,” For, 225th Annual Meeting, Amer. Chem. Soc., New Orleans, LA, March 23-27, 2003.

Boll, R. A., Malkemus, D. W. and Mirzadeh, S. “Production of Actinium-225 for Alpha Particle Mediated Radiotherapy,” For, Annual ANS Meeting, San Diego CA, June 1-5, 2003.

Brown, K. K., Winegar, D. A., Franklin, M. C., Michaud, E. and Knapp, F. F., Jr. “PPAR-Gamma Activation Restores Insulin Sensitivity and Improves the Ability of the Diabetic Mouse Heart to Transport and Utilize Glucose and Reduces Myocardial Triacylglycerol Accumulation,” American heart Association Meeting, Orlando, FL, November 9-12, 2003.

Craig, A. M., Marsh, D. J., Boll, R. A., Schweitzer, G. K. and Mirzadeh, S. “Recoil-Separation of ²²¹Fr from ²¹³Bi from ²²⁵Ac,” 225^th Annual Meeting, Amer. Chem. Soc., New Orleans, LA, March 23-27, 2003.

Garland, M. A. and Mirzadeh, S. “Alternative Routes for Production of ²²⁹Th, ²²⁵Ra and ²²⁵Ac, 225^th Annual Meeting, Amer. Chem. Soc., New Orleans, LA, March 23-27, 2003.

Garland, M. A. and Mirzadeh, S. “Reactor Production of Thorium-229,” Annual ANS Meeting, San Diego CA, June 1-5, 2003.

Knapp, F. F., Jr. “Production of Medical Radioisotopes in the ORNL HFIR - When is High Flux Needed ?” Invited Lecture, ANS Winter Meeting, New Orleans, LA, November 16-20, 2003.

Knapp, F. F., Jr. “Targeted Radiotherapy with Rhenium-188 - An Attractive Radioisotope for Broad Clinical Applications ,” Invited Plenary Lecture, European Nuclear Medicine Congress, Amsterdam, The Netherlands, August 23-27, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR),“ 15th International Radiopharmaceutical Symposium on Radiopharmaceutical Chemistry,“ Sydney, Australia, August 10-14, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Research Reactor (HFIR),” Invited Lecture, Eighth International Symposium, The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, Isotope Society, Boston, MA, June 1-5, 2003.

Knapp, F. F., Jr. “Current Clinical Applications of Rhenium-188 from the Tungsten-188/Rhenium-188 Generator,” Invited Lecture, Mediterranean Society for Nuclear Medicine and Radiopharmaceuticals, Athens, Greece, May 28 - June 1, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Research Reactor (HFIR) for Applications in Nuclear Medicine, Oncology and Interventional Cardiology,” Invited, MARC VI Conference on Radioanalytical Chemistry, Kona-Kailua, Hawaii, April 7-11, 2003.

Knapp, F. F., Jr. “New Developments with Unsealed Sources for Targeted Radiotherapy,” Invited Lecture, Annual Meeting, German Society of Nuclear Medicine, Essen, Germany, April 3-6, 2003 (Prof. Dr. Dr. A. Bockisch, Organizer).

Mirzadeh, S. “Actinium-225 Production at the Oak Ridge National Laboratory,” Invited Lecture, Alpha-Emitting Isotopes Workshop, Dubna, Russia, April 26, 2003.

Mirzadeh, S., Du., M., Beets, A. L. and Knapp, F. F., Jr. “Reactor Production of High Specific Activity Platinium-195m for Therapeutic Applications,” Invited Lecture, Annual Meeting, American Chemical Society, New York, NY, September 7-11, 2003.

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