Knapp, F. F., Jr., Mirzaeh, S., and Garland, M. “The Continuing Important Role of High Flux Reactors for Production of Therapeutic Medical Radioisotopes,” Invited Lecture, For, TECDOC, International Symposium on Trends in Radiopharmaceuticals, IAEA, Vienna, Austria, in press.

Boll, R. A., Malkemus, D. and Mirzadeh, S. “Production of Actinium-225 for Alpha Particle-Mediated Radioimmunotherapy,” Appl. Radiat. Isot., 62, 667-679 (2005).

Kennel, S. J., Lankford, P., Garland, M., Sundberg, J. P. and Mirzadeh, S. “Biodistribution of Ra-225 Citrate in Mice: Retention of Daughter Radioisotopes in Bone,“ Nucl. Med. Biol., 32, 859-867 (2005).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. ”Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor for Applications in Nuclear Medicine, Oncology and Interventional Cardiology,“ J. Radioanalyt. Nuc. Chem., 263 (2), 503-509 (2005).

Garland, M. A., Mirzadeh, S., Alexander, C. W., Hirtz, G. J., Hobbs, R. W. and Knapp, F. F., Jr. “Flux Characterization of the Peripheral Target Positions in the High Flux Isotope Reactor,” Appl. Radiat. Isot., 59, 63-72 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR),“ J. Label Cmpds. Radiopharm., 46 (Suppl. 1), S320(2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Garland, M. ”Production of Medical Radioisotopes in the ORNL High Flux Isotope Reactor,“ Transactions, American Nuclear Society, 89, 765-766 (2003).

Haverlock, T. J., Mirzadeh, S. and Moyer, B. A. “Selectivity of Calix[4]arene-bis(benzocrown-6) in the Complexation and Transport of Francium Ion,” J. Amer. Chem. Soc., 125, 1126-1127 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Mausner, L. F. and Mirzadeh, S. “Reactor Production of Radionuclides,” In, Handbook of Radiopharmaceuticals: Radiochemistry and Applications, M. J. Welch and C. Redvanly, Editors; John Wiley and Sons, Ltd., in press.

Mirzadeh, S., Mausner, L. F. and Garland, M. “Reactor-Produced Medical Radioisotopes,“ In, Handbook of Nuclear Chemistry, Volume 4, Chapter 3, pp. 1-46; A. Vertes, N. S. Klencsar, Editors; Kluwer Academic Publishers, Amsterdam (2003).

Ponsard, B., Mirzadeh, S. and Knapp, F. F., Jr. “Production of Tungsten-188 in the BR2 Reactor in Collaboration with ORNL,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Binney, S. E., Krane, K. S., Garland, M. A., Pertmer, G. A. and Mirzadeh, S. “Measurement of Neutron Cross Sections for Medical Isotopes,” Trans. Amer. Nucl. Soc., 86, 167-168 (2002).

Kennel, S. J., Lankford, T., Daven, S., Foote, L., Taniguchi, K., Ohizumi, Y., Nakagawa, S., Mayumi, T. and Mirzadeh, S. “Therapy of Rat Tracheal Carcinoma IC-12 in SCID Mice. Vascular Targeting with 213Bi-MAb TES-23,” Eur. J. Can., 1278-1287 (2002).

Kennel, S. J., Brechbiel, M. W., Schlom, J. and Mirzadeh, S. “Actinium-225 Conjugates of Mab CC49 and Humanized Delta CH2CC49,” Can. Biother. and Radiopharm., 17, 219-231 (2002).

Kennel, S. J., Mirzadeh, S., Eckelman, W. C., Waldmann, T. A., Garmestani, K., Yordanov, A. T., Stabin, M. G. and Brechbiel, M. W. “Vascular-Targeted Radioimmunotherapy with the Alpha-Particle Emitter, Astatine-211,” Radiat. Res., 157, 633-641 (2002).

Mirzadeh, S., Lambrecht, F. Y. and Lambrecht, R. M. “Decay of Tungsten-189,” Appl. Radit. Isot., 57, 637-646 (2002).

Milenic, D. E., Roselli, M., Mirzadeh, S., Pippin, C. G., Gansow, O. A., Colcher, D., Brechbiel, M. W. and Schlom, J. “In Vivo Evaluation of Bismuth-213-Labeled Monoclonal Antibody Comparing DTPA-Derived Bifunctional Chelates,” Can. Biother. Radiopharm., 16, 133-146 (2001).

Kennel, S. J., Lankford, T., Davern, S., Foote, L., Taniguchi, K., Ohizumi, I., Tsutsumi, Y., Nakagawa, S., Mayumi, T. and Mirzadeh, S. "Therapy of Rat Tracheal Carcinoma IC-12 in SCID Mice: Vascular Targeting with Bi-213-MAb TES-23," Int. J. Cancer, submitted.

Kennel, S. J., Mirzadeh, S., Hurst, G. B., Foote, L. J., Lankford, T. K., Glowienka, T. K., Chappell, L., Kelso, J. R., Davern, S. M., Safavy, A. and Brechbiel, M. W. "Labeling and Distribution of Linear Peptides Identified Using In Vivo Phage Display Selection for Tumors," J. Nucl. Med. Biol., 27, 815-825 (2000).

Kennel, S. J., Chappell, L. L., Dadchova, K., Brechbiel, M. W., Lankford, T. K., Davis, I. A., Stabin, M. and Mirzadeh, S. "Evaluation of ²²⁵Ac for Vascular-Targeted Radioimmunotherapy of Lung Tumors," Can. Biother. and Radiopharm., 15, 235-244 (2000).

Mirzadeh, S., Du, M., Beets, A.L. and Knapp, F. F., Jr. "Thermoseparation of Neutron-Irradiated Tungsten from Re and Os," Indust. Engineer. Chem. Res., 39, 3169-3172 (2000).

Wilson, L. J., Cagle, D. W., Thrash, T. P., Kennel, S. J., Mirzadeh, S., Alford, J. M. and Ehrhardt, G. J. "Mellalofullerene Drug Design," Coord Chem. Rev., 190, 199 (2000).

Cagle, D. W., Kennel, S. J., Mirzadeh, S., Alford, J. M. and Wilson, L. J. " In Vivo Studies of Fullerne-Based Materials Using Endohedral Metallofullerne Radiotracers," Proc. Natl. Acad. Sci., 96, 5182-5187 (1999).

Davis, I. A., Glowienka, K. A., Boll, R. A., Deal, K. A., Brechbiel, M. W., Stabin, M., Bocksler, P. N., Mirzadeh S. and Kennel, S. J. "Comparison of ²²⁵Actinium Chelates: Tissue Distribution and Radiotoxicity," Nucl. Med. Biol., 26, 581-589 (1999).

Deal, K. A., Davis, I. A., Mirzadeh, S., Kennel, S. J. and Brechbiel, M. W. "Improved In Vivo Stability of Actinium-225 Macrocyclic Complexes," J. Med. Chem., 42, 2988-2992 (1999).

Kennel, S. J. Boll, R., Stabin, M., Schuller, H. M. and Mirzadeh, S. "Radioimmunotherapy of Micrometastases in Lung with Vascular Targeted ²¹³Bi," Brit. J. Cancer, 80, 175-184 (1999).

Kennel, S. J., Lankford, P. K., Foote, L. J., Davis, I. A., Boll, R. A. and Mirzadeh, S. "Combination Vascular Targeted and Tumor Targeted Radioimmunotherapy," Cancer Biotherapy and Radiopharmaceuticals, 14, 371-379 (1999).

Kennel, S. J., Stabin, M., Yoriyaz, H., Brechbiel, M. and Mirzadeh, S. "Treatment of Lung Tumor Colonies with ⁹⁰Y Targeted to Blood Vessels: Comparison with the "-Particle Emitter ²¹³Bi," Nucl. Med. Biol., 26, 149-157 (1999).

Kennel, S. J., Stabin, M., Foote, L. J., Lankford, P. K.. Terzaghi-Howe, M., Patterson, H., Barkenbus, J., Popp, D. M., Boll, R. and Mirzadeh, S. "Toxicity and Microdosimetry for ²¹³Bi Bound to Membranes of Monolayer and Speroid Cultures of Tumor Cells," Radiation Res., 151, 244-256 (1999).

Thrash, T. P., Cagle D. W., Alford, J. M., Wright, K., Ehrhardt, G. J., Mirzadeh, S., Wilson L. J., "Toward Fullerene-Based Radiopharmaceuticals: High Yield Neutron Activation of Endohedral ¹⁶⁵Ho Metallofulerenes", Chemical Physics Letter, 12673 (1999).

Deal, K. A., Davis, I. A., Mirzadeh, S., Kennel, S. J., Brechbiel, M. W. "Improved In Vivo Stability of Actinium-225 Complexes", Journal of Medicinal Chemistry, 42, 2988-2992 (1999).

Davis, I. A., Glowienka, K. A., Boll, R. A., Deal, R. A., Brechbiel, M. W., Stabin, M, Bochsler, P. N., Mirzadeh, S., Kennel, S. J., "Comparison of Actinium-225 Chelates: Tissue Distribution and Radiotoxicity", Journal of Nuclear Medicine and Biology, 26, 581-589 (1999).

Kennel, S. J., Boll, R., Stabin, M., Schuller, H. M. and Mirzadeh, S., "Radioimmunotherapy of Micrometastases in Lung with Vascular Targeted ²¹³Bi", British Journal of Cancer, 80, 175-184 (1999).

Cagle D. W., Kennel, S. J., Mirzadeh, S., Alford, M. J., Wilson L. J., " In vivo Studies of Fullerene-based Materials Using Endohedral Metallofullerene Radiotracers" Proceedings of National Academy of Sciences, 96, 5182-5187 (1999).

Kennel, S. J., Stabin, M., Foote. L. J., Lankford, P. K., Terzaghi-Howe, M., Patterson, H., Barkenbus, J, Popp, D. M. and Mirzadeh, S., "Toxicity and Microdosimetry for ²¹³Bi Bound to Membranes of Monolayer and Spheroid Cultures of Tumor Cells", Radiation Research, 151, 244-256 (1999).

Kennel, S. J., Stabin, M., Yoriyaz, H., Brechbiel, M., and Mirzadeh, S., "Treatment of Lung Tumor Colonies with ⁹⁰Y Targeted to Blood Vessel - Comparison with the "-particle Emitter ²¹³Bi", Journal of Nuclear Medicine and Biology, 26, 149-157 (1999).

Kennel, S. J. and Mirzadeh, S., "Vascular Targeting for Radioimmunotherapy with ²¹³Bi -- an Alpha Particle Emitter", Journal of Nuclear Medicine and Biology, 25, 241-246 (1998).

Mirzadeh, S., "Generator-produced Alpha-emitters", Proceedings of CIRMS Medical Subcommittee Workshop on Radionuclides Used in Bone Pain Palliation Therapy NIST, Gaithersburg, Washington September 27, 1996, Applied Radiation and Isotopes, 49, 345-349 (1998).

Mirzadeh, S. and Walsh, P., "Numerical Evaluation of the Production of Radionuclides in a Nuclear Reactor - Parts I & II, Applied Radiation and Isotopes, 49, 379-382 (1998), and 49, 383-395 (1998).

McMurry, T. J., Pippin, G. C., Wu, C., Kim, D. A., Brechbiel, M. W., Mirzadeh, S., and Gansow, O. A., "Physical Parameters and Biological Stability of Yttrium(III) Diethylenetriaminepentaacetic Acid Derivative Conjugates" Journal of Medicinal Chemistry, 41, 3546-3549 (1998).

Boll, R. A., Mirzadeh, S. and Kennel, S. J., "Optimization of Radiolabeling of Immunoproteins with ²¹³Bi", Proceedings of Symposium on Radiochemistry and Radioimmunotherapy, 212th ACS National Meeting, Orlando, Fl, Aug. 24-28, 1996, Radiochimica Acta. 79, 145-179 (1997)

Kennel, S. J. and Mirzadeh, S., "Vascular Targeting for Radioimmunotherapy with ²¹³Bi". Proceedings of Symposium on Radiochemistry and Radioimmunotherapy, 212th ACS National Meeting, Orlando, Fl, Aug. 24-28, 1996, Radiochimica Acta. 79, 48-55 (1997)

Dadachova, E., Mirzadeh, S., Smith, S. V., Knapp, F. F. Jr. and Hetherington, E. L. "Radiolabeling Antibodies with Holmium-166", Applied Radiation and Isotopes, 48, 477-481 (1997).

Dadachova, E. and Mirzadeh, S., "The Role of Tin in Direct Labeling of Proteins with Rhenium-188", J. Nuclear Medicine and Biology, 6, 605-608 (1997).

Mirzadeh, S., C. W. Alexander and F. F. Knapp, Jr., "Evaluation of Neutron Inelastic Scattering, [n,n'], for Production of High Spin ^117mSn, ^119mSn and ^195mPt Isotopes", Applied Radiation and Isotopes, 48, 441-446 (1997).

Mirzadeh, S. and Knapp, F. F. Jr., "Biomedical Generator Systems", Journal of Radioanalytical and Nuclear Chemistry - Articles, 203, 469-486 (1996).

Dadachova, E., Mirzadeh, S. and Lambrecht, R. M., "Tungstate-Ion-Alumina Interaction in a¹⁸⁸W 6¹⁸⁸Re Biomedical Generator", Journal of Physical Chemistry 99, 10976-10981 (1995).

Patents

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. ”High Specific Activity Platinum-195m,“
U. S. Patent No. 6,804,319, Issued October 12, 2004.

Beets, A. L., Du, M., Mirzadeh, S. and Knapp, F. F., Jr. “Method for Preparation of High Specific Activity Reactor-Produced Lutetium-177,” U.S. Patent No. 6,716,353, Issued April 5, 2004.

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. “New Method for Preparation of High Specific Activity Platinum-195m for Medical Therapy,” U. S. Patent No. 6,751,280, Issued June 15, 2004.

Knapp, Jr., F. F., Beets, A. L., Mirzadeh, S. and Guhlke, S. “Concentration of Perrhenate and Pertechnetate Solutions,” U.S. Patent No. 5,729,821, Issued March 17, 1998.

Mirzadeh, S., Knapp, Jr., F. F. and Collins, E. D. "A Tandem Radioisotope Generator System for Preparation of Highly Concentrated Solutions of Tc-99m from Low Specific Activity Mo-99,” U.S. Patent No. 5,774,782, Issued June 30, 1998.

Mirzadeh, S. and Kennel, S. J. “Bismuth-213 Generator,” Disclosed.

Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S. and Callahan, A. P. "Tungsten 188/Carrier-Free Rhenium 188 Perrhenic Acid Generator System," U.S. Patent No. 5,275,802, Issued January 4, 1994.

Dr. Mirzadeh has an additional 40 publications in refereed Journals, and over 50 contributions as Book Chapters, Monographs and Proceedings.

Please direct correspondence to:

Saed Mirzadeh, Ph.D • Building 4501, MS-6229 • Oak Ridge National Laboratory • Oak Ridge, TN 37831-6229 • Phone: 865-574-8399 • Fax: 865-574-6226 • E-mail: mirzadehs@ornl.gov


This site was updated 01/23/02
Back to Publications page