Knapp, F. F., Jr., Mirzaeh, S., and Garland, M. “The Continuing Important Role of High Flux Reactors for Production of Therapeutic Medical Radioisotopes,” Invited Lecture, For, TECDOC, International Symposium on Trends in Radiopharmaceuticals, IAEA, Vienna, Austria, in press.

Monroy-Guzman, F., Badillo Almaraz, V. E., Flores de la Torre, J. A., Cosgrove, J. M. and Knapp, F. F., Jr. “Hydroxyapatite-Based Mo-99/Tc-99m and W-188/re-188 Generator Systems,” For, TECDOC, International Symposium on Trends in Radiopharmaceuticals, IAEA, Vienna, Austria, in press.

Knapp, F. F., Jr. “Therapeutic Applications of Rhenium-188 in Nuclear Medicine and Oncology – Current Status and Future Perspectives,” Invited Lecture, For, International Conference on Radiopharmaceutical Therapy, World Radiopharmaceutical Therapy Council, WFNMB, Limassol, Cyprus, October 11-14, 2005.

Knapp, F. F., Jr., Mirzadeh, S., Stabin, M. and Brill, A. B. ”Therapy with High LET Radioisotopes – Can Sufficient Levels of Attractive Auger and Alpha Emitters be Produced to Make Their Use Practical ?,” Invited Lecture, For, International Conference on Radiopharmaceutical Therapy, World Radiopharmaceutical Therapy Council, WFNMB, Limassol, Cyprus, October 11-14, 2005.

Knapp, F. F., Jr. “Therapeutic Applications of Rhenium-188 in Nuclear Medicine and Oncology – Current Status and Future Perspectives,” For, Symposium on Radioisotope Therapy, Havana, Cuba, June 24-28, 2005.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du., M., Klein, J. A. and Garland, M. “Direct Production of Lutetium-177 from Enriched Lu-176 in a High Flux Reactor – The Only Practical Route to Provide High Specific Activity/Multi-Curie Levels of Lu-177 Required fro Routine Clinical Use,“ For, 5th International Conference on Isotopes (5ICI), Brussels, Belgium, April 24-29, 2005.

Knapp, F. F., Jr. “The Important Role of Research Reactors for Production of Medical Radioisotopes,” Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea, April 15, 2005.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. ”Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor for Applications in Nuclear Medicine, Oncology and Interventional Cardiology,“ J. Radioanalyt. Nuc. Chem., 263 (2), 503-509 (2005).

Knapp, F. F., Jr., Turner, J. H., Jeong, J.-M. and Padhy, A. K. “Issues Associated with the Use of the Tungsten-188/Rhenium-188 Generator and Concentration System and Preparation of Re-188-HDD,” World Journal of Nuclear Medicine, 3, 137-143 (2004).

Reynen, K., Kockeritz, U., Kropp, J., Wunderlich, G., Knapp, F. F., Schmeisser, A, and Strasse, R. H. ”Intracoronary Radiotherapy with a Rhenium-188 Liquid-Filled PTCA Balloon System in In-Stent Restenosis: Acute and Long-Term Angiographic Results, as well as 1 Year Clinical Follow-up,” Internat. J. Card., 95, 29-34 (2004).

Garland, M. A., Mirzadeh, S., Alexander, C. W., Hirtz, G. J., Hobbs, R. W. and Knapp, F. F., Jr. “Flux Characterization of the Peripheral Target Positions in the High Flux Isotope Reactor,” Appl. Radiat. Isot., 59, 63-72 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR),“ J. Label Cmpds. Radiopharm., 46 (Suppl. 1), S320 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Garland, M. ”Production of Medical Radioisotopes in the ORNL High Flux Isotope Reactor,“ Transactions, American Nuclear Society, 89, 765-766 (2003).

Knapp, F. F., Jr. and Kropp, J. “The 11th Mediterranean Meeting on Nuclear Medicine and Radiopharmaceuticals,“ Eur. J. Nucl. Med., 30, 1701-1702 (2003).

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Franke, W.-G. "Radiation Dosimetry of Rhenium-188-HEDP in the Therapy of Painful Bone Metastases," J. Nucl. Med., submitted.

Palmedo, H., Manka-Waluch, A., Albers, P., Schmidt, W., Guhlke, S., Reinhardt, M., Ezziddin, S., Joe, A., Roedel, R., Fimmers, H., Knapp, F. F., Jr. and Biersack, H.-J. “Repeated Bone Targeted Therapy for Hormone-Refractory Prostate Carcinoma: Randomized Phase II Trial with the New, High-Energy Radiopharmaceutical Rhenium-188-HEDP,” J. Clin. Oncol., 21, 2869-2875 (2003).

Ponsard, B., Hiltunen, J., Vera-Ruiz, H., Beets, A. L., Mirzadeh, S. and Knapp, F. F., Jr. “The Tungsten-188/Rhenium-188 Generator: Effective Coordination of Tungsten-188 Production Between the HFIR and BR2 Reactors,” J. Radioanalyt. Nucl. Chem., 257, 169-174 (2003).

Sloof, G. W., Knapp, F. F., Jr., van Lingen, A., Eersels, J., Poldermans, D. and Bax, J. J. “Nuclear Imaging Is More Sensitive For the Detection of Viable Myocardium Than Dobutamine Echocardiography,” Nuclear Med. Commun., 24, 357-381 (2003).

Verberne, H. J., Sloof, G. W., Beets, A. L., Murphy, A. M., van Eck-Smit, N. L. F. and Knapp, F. F., Jr. “Free Fatty Acid and Glucose Uptake in a Transgenic Mouse Model of Stunned Myocardium,” Eur. J. Nucl. Med., 30, 431-439 (2003).

Granadas, O. H., Stevens, S. L., Donnell, R. L., Costanza, M. J., Spencer R. H., Knapp, F. F., Jr., Shoieb, A. M., Brown, K. J., Reddick, T. T., Freeman, M. B. and Goldman, M. H. "Effect of Intravascular Radiation on the Distribution of Macrophages, Platelet-Derived Growth Factor and Transforming Growth Factor in the Swine Iliac Artery," Annals Vasc. Surg., in press.

Knapp, F. F., Jr., “Radionuclide Generators: Their Continuing Important Role to Provide Radioisotopes for Diagnosis and Therapy,” J. Nucl. Med., Invited Continuing Education Review, in preparation.

Liepe, K., Hliscs, R., Kropp, J., Ningl, T. G., Runge, R., Koch, R., Knapp, F. F., Jr. and Franke, W.-G. "Rhenium-188-HEDP in the Palliative Treatment of Bone Metastases," Eur. J. Nucl. Med., submitted.

Zetting, G., Dobrozemsky, G., Kirisits, C., Wexberg, P., Cejna, M., Mitterhauser, Knapp, F. F., Jr. and Dudczak, R. "Endovascular Radiation with Liquid-Filled Balloons - The Impact of Reused Balloon Catheters on the Projected Dose," Appl. Radiat. Isot., submitted

Buhman, K. K., Smith, S. J., Stone, S., Repa, J., Wong, J. S., Knapp, F. F., Jr., Burri, B., Hamilton, R. L., Abumrad, N. A. and Farese, R. V., Jr. “DAGAT1 Is Not Essential for Intestinal Triacylglycerol Absorption or Chylomicron Synthesis,” J. Biol. Chem., 277, 25474-25479 (2002).

Febbraio, M., Guy, E., Coburn, C., Knapp, F. F., Jr., Beets, A. L., Abumrad, N. A. and Silverstein, R. L. “The Impact of Overexpression and Deficiency of Fatty Acid Translocase (FAT)/CD36,” Mol. Cell. Biochem., 239, 193-197 (2002).

Hambye, A.-S., Dobbelier, A., Vervaet, A. and Knapp, F. F., Jr. “Image Quality of Rhenium-188 and Technetium-99m - Comparative Planar and SPECT Evaluation in a Phantom Study - Implications for Dosimetric Calculation,” World J. Nucl. Med., 1, 12-20 (2002).

Chen, F. D., Wang, H. E., Ou, Y. H., Yang, W. K., Peng, J. W., Liu, R. S., Knapp, F. F., Jr., Hsieh, B. T., Ting, G. and Yen, S. H. "Efficacy of Re-188-Labeled Sulfur Colloid on Prolongation of Survival Time in Melanoma-Bearing Animals," Nucl. Med. Biol., 28, 835-844 (2001).

Hajri, T., Ibrahimi, A., Coburn, C., Knapp, F. F., Jr., Kurtz, T., Pravenec, M. and Abumrad, N. A. "Defective Fatty Acid Uptake in the Spontaneously Hypertensive Rat Is a Primary Determinant of Altered Glucose Metabolism and Hyperinsulinemia," J. Biol. Chem., 276, 23661-23666 (2001).

Knapp, F. F., Jr., Spencer, R. and Kropp, J. "Intravascular Radiation Therapy with Radioactive Liquid-Filled Balloons for inhibition of Restenosis After Angioplasty - A New Opportunity for Nuclear Medicine ?," J. Nucl. Med., 42, 1384-1387 (2001).

Knapp, F. F., Jr. "Future Prospects for Medical Radionuclide Production in the High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL)," Annals of Nucl. Med. Sci. (Taiwan), 14, 109-118 (2001).

Lisic, E. C., Philips, M., Ensor, D., Nash, K. L., Beets, A. L. and Knapp, F. F., Jr. "Synthesis of a New Bisphosphonic Acid Ligand (SEDP) and Preparation of a ¹⁸⁸Re-(Sn)SEDP Bone Seeking Radiotracer," Nucl. Med. Biol, 28, 419-424 (2001).

McPherson, D. W., Breeden, W., III, Beets, A. L., Luo, H., Sood, V. and Knapp, F. F., Jr. "Synthesis, In Vitro and In Vivo Evaluation of the Stereoisomers of 1-Methylpiperidin-4-yl alpha-Hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate as Potential Ligands for the Imaging of the Muscarinic Receptor," Nucl. Med. Biol., 28, 959-973 (2001).

Oh, S. J., Moon, D. H., Ha, H.-J., Park, A. W., Hong, M. K., Park, S. J., Choi, T. H., Lim, S. M., Choi, C. W., Knapp, F. F., Jr. and Lee, H. K. "Synthesis of Highly Concentrated ¹⁸⁸Re-MAG3 and Automation for Intracoronary Radiation Therapy," Appl. Rad. Isot., 54, 419-427 (2001).

Pirmettis, I., Limouris, G. S., Bouziotis, P., Papadopolous, M., Knapp, F. F., Jr. and Chiotellis, E. "Pentavalent Rhenium-188 Dimercaptosuccinic Acid: A New Kit Formulation and its Initial Evaluation in Mice," Radiochmica Acta, 89, 115-118 (2001).

Savio, E., Gaudiano, J., Robles, A., Martinez, G., Leon, A., Veredra, S., Muniz, S., Hermida, J. C. and Knapp, F. F., Jr. "Rhenium-188-HEDP: Pharmacokinetic Characterization in Osseous Metastatic Patients with Two Levesl of Radiopharmaceutial Dose," BMC Nucl. Med., 1 (23), 1471-1485 (2001).

Wang, S.-J., Lin, W.-Y., Chen, M. N., Chen, J. T., Ho, W. L., Hsieh, B. T., Huang, H., Shen, L. H., Ting G. and Knapp, F. F., Jr. "Histologic Study of Effects of Radiation Synovetcomy with Rhenium-188 Microsphere," Nucl. Med. Biol., 28, 727-732 (2001).

Book Chapters, Meeting Proceedings, and Special Publications

Knapp, F. F., Jr., Cosgrove, J. M. and Porter, C. E. “The Tungsten-188/Rhenium-188 Generator – An Attractive Cost Effective Source of Rhenium-188 for Clinical Use,” Technical Document (TECDOC) # , Research Coordination Meeting (RCM) on Radionuclide Generators, International Atomic Energy Agency (IAEA), Vienna, Austria, October 4-8, 2004.

Bax, J. J., Knapp, F. F., Jr. and Visser, F. C. “Single-Photon Imaging of Myocardial Metabolism: Role of Iodine-123 Fatty Acids and Fluorine-18 Deoxyglucose,” In, Nuclear Medicine in Clinical Diagnosis and Treatment; P. J. Ell and S. S. Gambhir, Editors; 3rd Edition, Churchill Livingston, Edinburgh, 2004 (ISBN 0 443 07312 0).

Iyer, S. R. and Knapp, F. F., Jr. Editors, for, “Manual for Reactor Production of Radioisotopes,” International Atomic Energy Agency (IAEA), TECDOC-1340; Vienna, Austria, January 2003. (ISBN-92-0-101103-2).

Knapp, F. F., Jr. “Applications of Rhenium-188-Labeled Agents in Oncology,” In, Proceedings, the 11th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 147-156 (2003).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Kropp, J., Pinkert, J., Wunderlich, G., and Knapp, F. F., Jr., “Radiohchemistry, Evaluation and First Clinical Results in the Treatment of Oncologic Diseases with Rhenium-188-Labeled Microspheres,” In, Proceedings, the 11th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 157-166 (2003).

Liepe, K., Kropp, J., Hliscs, R., Runge, R., Knapp, F. F., Jr. and Kotzerke, J. ”Rhenium-188 HEDP Dosimetry in Bone Pain Induced by Prostate Cancer,” In, Proceedings, the 11th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, May 28-30, Athens, Greece; Medittera Pub., Athens (ISBN 960-86437-2-4), pp. 69-82 (2003).

Ponsard, B., Mirzadeh, S. and Knapp, F. F., Jr. “Production of Tungsten-188 in the BR2 Reactor in Collaboration with ORNL,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Roesch, F. and Knapp, F. F., Jr. “Radionuclide Generators,“ In, Handbook of Nuclear Chemistry, Volume 4, Chapter 3, pp. 81-118; A. Vertes, N. S. Klencsar, Editors; Kluwer Academic Publishers, Amsterdam (2003).

Weinberger, J. and Knapp, F. F., Jr. “Use of Liquid-Filled Balloons for Coronary Irradiation,” In, Vascular Brachytherapy, R. Waksman, Editor, Third Edition, Futura Publishing Co., Inc., Armonk, NY, pp. 753-790 (2002).

Gaudiano, J., Savio, E., Robles, A., Muniz, S., Leon, A., Verdera, S., Martinez, G., Hermida, J. C. and Knapp, F. F., Jr. “Rhenium-188-HEDP in the Treatment of Pain in Bone Metastases,” In, Proceedings (IAEA/TECDOC-1228), International Seminar on Therapeutic Applications of Radiopharmaceuticals (IAEA-SR-209), Hyderabad, India, January 18-22, 1999; pp 215-220 (2001).

Knapp, F. F., Jr., Beets, A. L., Pinkert, J., Kropp, J., Lin, W.-Y. and Wang, S.-Y. “Rhenium Radioisotopes for Radiopharmaceutical Development,” In, Proceedings (IAEA/TECDOC-1228), International Seminar on Therapeutic Applications of Radiopharmaceuticals (IAEA-SR-209), Hyderabad, India, January 18-22, 1999; pp 59-66 (2001).

Knapp, F. F., Jr. “Radiopharmaceuticals for Inflammation/infection Imaging - From Gallium-67 to 2-[F-18]-2-Fluoro-2-Deoxyglucose,” In, Proceedings, 10th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, Athens, Greece, May 29-31, 2001; Mediterrea, Athens, pp 19-26 (2001) (ISBN 960-86437-1-6).

Knapp, F. F., Jr. “Fatty Acids for Myocardial Imaging,” In, Syllabus/Proceedings, 6th Annual American Society of Nuclear Cardiology (ASNC) Symposium and Scientific Session, Boston, MA, September 13-16, 2001; ASNC pp 74-78 (2001).

Knapp, F. F., Jr. and Kropp, J. “ The 10th Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals,” News and Views, Eur. J. Nucl. Med., 28, 1878 (2001).

Patents

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. ”High Specific Activity Platinum-195m,“
U. S. Patent No. 6,804,319, Issued October 12, 2004.

Beets, A. L., Du, M., Mirzadeh, S. and Knapp, F. F., Jr. “Method for Preparation of High Specific Activity Reactor-Produced Lutetium-177,” U.S. Patent No. 6,716,353, Issued April 5, 2004.

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. “New Method for Preparation of High Specific Activity Platinum-195m for Medical Therapy,” U. S. Patent No. 6,751,280, Issued June 15, 2004.

Knapp, Jr., F. F., Beets, A. L., Mirzadeh, S. and Guhlke, S. “Concentration of Perrhenate and Pertechnetate Solutions,” U.S. Patent No. 5,729,821, Issued March 17, 1998.

Mirzadeh, S., Knapp, Jr., F. F. and Collins, E. D. "A Tandem Radioisotope Generator System for Preparation of Highly Concentrated Solutions of Tc-99m from Low Specific Activity Mo-99,” U.S. Patent No. 5,774,782, Issued June 30, 1998.

Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S. and Callahan, A. P. "Tungsten 188/Carrier-Free Rhenium 188 Perrhenic Acid Generator System," U.S. Patent No. 5,275,802, Issued January 4, 1994.

Knapp, Jr., F. F. "Radioiodinated Agent to Evaluate Gastrointestinal Disease by Urine Analysis” The "Wuerfel Test", Disclosed.

Knapp, Jr., F. F., Lisic, E. C., Mirzadeh, S., and Callahan, A. P. "Tungsten 188/Carrier-Free Rhenium 188 Perrhenic Acid Generator System," U.S. Patent No. 5,186,913, Issued February 17, 1993.

Goodman, M. M., and Knapp, Jr., F. F. "Aminopropyl Thiophene Compounds," U.S. Patent 4,914,215, Patent Gazette, April 3, 1990.

Goodman, M. M. and Knapp, Jr., F. F. "Radiohalogenated Thienylamphetamine Derivatives for Evaluating Local Cerebral Blood Flow," U.S. Patent 4,900,539, Patent Gazette, p. 925, February 13, 1990.

Goodman, M. M., and Knapp, Jr., F. F. "Radioiodinated Branched Carbohydrates," U.S. Patent 4,826,966, Patent Gazette, May 2, 1989.

Meeting Presentations and Published Abstracts

Knapp, F. F., Jr. “The Production and Use of Therapeutic Radionuclides for Nuclear Medicine and Oncology Applications,” Invited Lecture, Hannoro 2005 Conference – The 10th Anniversary, Korea Atomic Energy Research Institute (KAERI), April 11-13, 2005.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du., M., Klein, J. A. and Garland, M. “Direct Production of Lutetium-177 from Enriched Lu-176 in a High Flux Reactor – The Only Practical Route to Provide High Specific Activity/Multi-Curie Levels of Lu-177 Required fro Routine Clinical Use,“ For, 5th International Conference on Isotopes (5ICI), Brussels, Belgium, April 14-19, 2005.

Chen, L., Wang, W. D., Chen, Y. C. and Knapp, F. F. “Generator Elution and Concentration of Rhenium-188,“ 51st Annual Meeting, Society of Nuclear Medicine, J. Nucl. Med., 44, Abstract # 1517 (2004).

Knapp, F. F., Jr. “Rhenium-188 and Lutetium-177– Reactor Production and Development and Applications of Therapeutic Radiopharmaceuticals,” Invited Lecture, 6th International Radiopharmaceutical Therapy Colloquium, Pre-Congress Meeting, held in association with, 8th Congress of the Asia and Oceania Federation of Nuclear Medicine and Biology, Beijing, China, October 9, 2004.

Knapp, F. F., Jr. “Rhenium-188 – A Generator-Derived Radioisotope with Broad Therapeutic Applications in Nuclear Medicine and Oncology,” Invited Lecture, Research Coordination Meeting on Radionuclide Generator Technologies for Therapeutic Radionuclides, International Atomic Energy Agency (IAEA), Vienna, Austria, October 4-7, 2004.

Knapp, F. F., Jr. , “Rhenium-188 Agents for Liver Cancer Therapy – Current Status and Future Perspectives,” Inaugural Clinical Investigators Meeting for the Proposed European/Asia and Oceania Phase I/II Study on Rhenium-188-DEDC Lipiodol Intrahepatic Arterial Therapy of Hepatocellular Carcinoma, Ferrara, Italy, September 9, 2004; Pre-Congress Symposium of the Annual European Association of Nuclear Medicine Congress, Helsinki, Finland, Sept. 4-8, 2004.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du, M. and Garland, M. ”Reactor Production of High Specific Activity Lutetium-177,“ Eur. J. Nucl. Med., 31, Suppl. 2, S387 (2004) (Poster # 455).

Knapp, F. F., Jr., “Rhenium-188 for Cancer Therapy – A Reactor-Produced Radioisotope with Broad Applications in Nuclear Medicine and Oncology,” NNSA/NA-243 Sister Laboratory Expert Mission, Institute for Nuclear Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr., “Reactor-Produced Therapeutic Radioisotopes,” NNSA/NA-243 Sister Laboratory Expert Mission, Institute for Nuclear Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr. “Molybdenum-99 – Advantages for Direct Production from Mo-98 Versus Fission Production,” NNSA/NA-243 Sister Laboratory Expert Mission, Institute for Nuclear Research (INR/ICN), Pitesti, Romania, September 13-15, 2004.

Knapp, F. F., Jr., Mirzadeh, S., Beets, a. L., Du. M. and Garland, M. “Reactor Production of High Specific Activity Lutetium-177,“ Eur. J. Nucl. Med., 31 (Suppl. 2), S387 (2004).

Knapp, F. F., Jr. “New Developments with Unsealed Sources for Targeted Radiotherapy,” Invited Lecture, 51st Bad Gastein Lecture, Bad Gastein, Austria, January 14-17, 2004.

Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser, A., Knapp, F. F. and Strasser, R. R. “Intracoronary Radiotherapy with Re-188 Liquid-Filled Balloon: The Dresden Prospective, Randomized, Placebo-Controlled, Double-Blind, In Stent Restenosis Trial (DRAIN),“ 51st Annual Meeting, Society of Nuclear Medicine, J. Nucl. Med., 44, Abstract # 802 (2004).

Brown, K. K., Winegar, D. A., Franklin, M. C., Michaud, E. and Knapp, F. F., Jr. “PPAR-Gamma Activation Restores Insulin Sensitivity and Improves the Ability of the Diabetic Mouse Heart to Transport and Utilize Glucose and Reduces Myocardial Triacylglycerol Accumulation,” American Heart Association Meeting, Orlando, FL, November 9-12, 2003.

Knapp, F. F., Jr. “Production of Medical Radioisotopes in the ORNL HFIR - When is High Flux Needed ?” Invited Lecture, ANS Winter Meeting, New Orleans, LA, November 16-20, 2003.

Knapp, F. F., Jr. “Targeted Radiotherapy with Rhenium-188 - An Attractive Radioisotope for Broad Clinical Applications ,” Invited Plenary Lecture, European Nuclear Medicine Congress, Amsterdam, The Netherlands, August 23-27, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR)," 15th International Radiopharmaceutical Symposium on Radiopharmaceutical Chemistry, Sydney, Australia, August 10-14, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Research Reactor (HFIR),” Invited Lecture, Eighth International Symposium, The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, Isotope Society, Boston, MA, June 1-5, 2003.

Knapp, F. F., Jr. “Current Clinical Applications of Rhenium-188 from the Tungsten-188/Rhenium-188 Generator,” Invited Lecture, Mediterranean Society for Nuclear Medicine and Radiopharmaceuticals, Athens, Greece, May 28 - June 1, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Research Reactor (HFIR) for Applications in Nuclear Medicine, Oncology and Interventional Cardiology,” Invited, MARC VI Conference on Radioanalytical Chemistry, Kona-Kailua, Hawaii, April 7-11, 2003.

Knapp, F. F., Jr. “New Developments with Unsealed Sources for Targeted Radiotherapy,” Invited Lecture, Annual Meeting, German Society of Nuclear Medicine, Essen, Germany, April 3-6, 2003 (Prof. Dr. Dr. A. Bockisch, Organizer).

Mirzadeh, S., Du., M., Beets, A. L. and Knapp, F. F., Jr. “Reactor Production of High Specific Activity Platinium-195m for Therapeutic Applications,” Invited Lecture, Annual Meeting, American Chemical Society, New York, NY, September 7-11, 2003.

Knapp, F. F., Jr. and Biersack, H.-J., Co-Chairs, Round Table Discussion on “Current Status and Future Clinical Applications of the Tungsten-188/Rhenium-188 Generator,” World Federation of Nuclear Medicine and Biology (WFNMB) Meeting, Santiago, Chile, September 29, 2002.

Knapp, F. F., Jr. “Production of Therapeutic Radioisotopes in the High Flux Isotope Reactor (HFIR),” Invited Lecture, COST D18 Meeting, Heidelberg, Germany, July 22-25, 2002.

Knapp, F. F., Jr. “Rhenium-188 - Advantages and Clinical Potential for Use of a Readily Available, Cost Effective Therapeutic Radioisotope for Applications in Nuclear Medicine, Oncology and Interventional Cardiology,” Invited Lecture, 25 International Symposium on Radioactive Isotopes in Clinical Medicine and Research, Bad Gastein, Austria, January 8-11, 2002; Eur. J. Nucl. Med., 29, S5 (2002).

Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser. A., Strasser, R. H. and Knapp, F. F., Jr. “Prevention of In-Stent Restenosis with Liquid-Filled 188Re Balloon: The Dresden In-Stent Restenosis Trial (DIRRT),” World Federation of Nuclear Medicine and Biology Congress, Santiago, Chile, Sept. 30-Oct. 4, 2002; World J. Nucl. Med., 1, Suppl. 2, S13 (Abstract # 22) (2002).

Kropp, J., Schmidt, S., Wunderlich, G., Schendtke, K. U., Breidert, M., McPherson, D. W. and Knapp, F. F., Jr. “A New and Simple test for Exocrine Function of the Pancreas: Analysis of the Urine After Oral Application of an I-131-Labeled Triglyceride,” World Federation of Nuclear Medicine and Biology Congress, Santiago, Chile, Sept. 30-Oct. 4, 2002; World J. Nucl. Med., 1, Suppl. 2, S50 (Abstract # 103) (2002).

Liepe, K., Hliscs, R., Knapp, F. F., Jr. and Kropp, J. “Dosimetry and Therapeutic Effect of 188Re-HEDP in Human Prostate Cancer Skeletal Metastases,” Third North American Symposium on Skeletal Complications of Malignancy, National Institutes of Health, Bethesda, MD, April 24-27, 2002.

Ponsard, B., Hiltunen, J., Vera Ruiz, H., Beets, A. L., Mirzadeh, S. and Knapp, F. F., Jr. “The Tungsten-188/Rhenium-188 Generator: Effective Coordination of Tungsten-188 Production Between the HFIR and BR2 Reactors,” In, Proceedings, Fourth International Conference on Isotopes (4ICI), Cape Town, South Africa, March 10-14, 2001.

Brown , K. K., Franklin, M., Binz, J. G., Henke, B. R., Winegar, D., Taj, S., Bharhawani, R., Michaud, E. J., Jones, B. H., Beets, A. L. and Knapp, F. F., Jr. “Treatment of db/db Mice with a Novel Insulin-Sensitizing Drug GW929 Alters Glucose and Lipid Uptake and Metabolism as Determined by Gene Expression and Tracer Studies [I-125]-BMIPP and [F-18]-2-FDG,” Regulation of Energy Metabolism in the Heart and Vasculature, Satellite Meeting of the 21st Annual Meeting of the International Society for Heart Research (ISHR), Banff, Canada, July 2-5, 2001;J. Mol. Cell. Card., 33, A163, 2001 (Abstract).

Knapp, F. F., Jr., Beets, A. L., Michaud, E. J., Jones, B. H., Verberne, H. J., Sloof , G., Brown, K. K. and Henke, B. R. “Treatment of Diabetic db/db mice with the New Insulin-Sensitizing Drug GW929 Results in Alterations in Glucose and Handling and Lipid Metabolism - Studies with [I-125]-BMIPP and [F-18]-2-FDG,” European Nuclear Medicine Congress, Naples, Italy, August 24-28, 2001; Eur. J. Nucl. Med., 42, 1016 (Abstract # OS-210).

Liepe, K., Hliscs, R., Kropp, J., Runge, R., Knapp, F. F. and Franke, G. W. “Radiation Absorbed Dose of Rhenium-188-HEDP in Bone Marrow and Bone Surface,” European Nuclear Medicine Congress, Naples, Italy, August 24-29, 2001; Eur. J. Nucl. Med., 42, 1055 (Abstract # OS-365).

Knapp, F. F., Jr. “Radiopharmaceuticals for Inflammation/Infection Imaging - From Gallium-67 to 2-FDG,” Invited Lecture, 11th International Mediterranean Symposium on Nuclear Medicine and Radiopharmaceuticals, Athens, Greece, May 29-June 3, 2001.

Knapp, F. F. “Availability and Use of the Tungsten-188/Rhenium-188 Generator System ,” IAEA Research Coordination Meeting on, Use of Rhenium-188 for Intravasculature Radiation Therapy for Restenosis Therapy After PTCA, Dresden, Germany, May 8-11, 2001, Invited Lecture.

Knapp, F. F., Jr. “Myocardial Imaging with Iodine-123-BMIPP - Issues, Practice and Future,“Invited Lecture, Teaching Faculty, For, 6th Annual American Association of Nuclear Cardiology, Symposium and Scientific Session, Boston, MA, September 13-16, 2001 (Meeting Cancelled Resulting from Sept. 11 Tragedy).

Knapp, F. F., Jr. “Therapeutic Applications of Rhenium-188 - New Opportunities for Nuclear Medicine, Oncology and Interventional Cardiology,” IAEA Symposium, European Nuclear Medicine Congress, Naples, Italy, August 24-29, 2001 (Invited).

Knapp, F. F., Jr. ”Reactor-Produced Medical Radioisotopes,” Institute of Energy Research (INER), Taipei, Taiwan, January 18, 2001 (Invited).

Kropp, J., Reynen, K., Koeckeritz, U., Wunderlich, G., Schmeisser, A., Knapp, F. F., Jr. and Franke, W.-G. “ Prevention of In-Stent Restenosis with Liquid-Filled 188Re Balloon: The Dresden In-Stent Restenosis Radiation Trial (DIRRT),” European Nuclear Medicine Congress, Naples, Italy, August 24-28, 2001, Eur. J. Nucl. Med., 42, 994 (Abstract # OS-127).

Liepe, K., Hliscs, R., Kropp, J., Knapp, F. F. and Franke, G. W. “Bone Marrow Radiation Dose of Rhenium-188-HEDP in Palliative Treatment of Metastatic Bone Pain,” J. Nucl. Med., 42, 23P (2001) (Abstract).

Verberne, H. J., Sloof, G. W., Beets, A. L., Slverstein, R. L., Murphy, A. M. and Knapp, F. F., Jr. “Decreased 2-FDG Uptake in a Troponin I Transgenic Mouse Model of Stunned Myocardium in the Presence of Normal Flow and Normal Fatty Acid Uptake,” 5th International Conference of Nuclear Cardiology, Vienna, Austria, May 2-5, 2001.

Blower, P. J., Kettle, A. G., O’Doherty, M. J., Coakley, A. J. and Knapp, F. F., Jr. “99mTc(V)DMSA Quantitatively Predicts 188Re(V)DMSA Distribution,” 28th Annual Meeting, British Nuclear Medicine Society, Brighton, UK, April 10-12, 2000; Nucl. Med. Commun., 21, 370 (2001).

Eidherr, H., Mitterhauser, M., Krcal, A., Bartosch, E., Zettining, G., Knapp, F. F., Jr. and Dudczak, R. “Evaluation of the 188W/188Re Generator and Online Concentration System,” In, Proceedings, 24th International Symposium on Radioactive Isotopes in Clinical Medicine and Research, Bad Gastein, Austria, January 11-14, 2000; Eur. J. Nucl. Med., 27, S95 (2001).

Blower, P. J., Kettle, A. G., O’Doherty, M. J. O., Coakley, A. J. and Knapp, F. F., Jr. "^99mTc(V)- DMSA Quantitatively Predicts ¹⁸⁸Re(V)DMSA Distribution in Patients with Prostate Cancer Metastatic to Bone," Eur. J. Nucl. Med., 27, 1407-1409 (2000).

Eidherr, H., Mitterhauser, M., Krcal, A., Bartosch, E., Zettining, G., Knapp, F. F., Jr. and Dudczak, R. “Evaluation of the 188W/188Re Generator and Online Concentration System,” In, Proceedings, 24th International Symposium on Radioactive Isotopes in Clinical Medicine and Research, Bad Gastein, Austria, January 11-14, 2000; Eur. J. Nucl. Med., 27, S95 (2001).

Breeden, W. F., Hamby, D. M., Carey, J. E., Eckerman, K. F., McPherson, D. W. and Knapp, F. F., Jr. "In Vivo Biodistribution of ¹²⁵I-IPIP and Internal Dosimetry of ¹²³I-IPIP Radioiodinated Agents Selective to the Muscarinic Acetylcholinergic Receptor Complex," Med. Physics, 27, 778-786 (2000).