Miting Du, Ph.D
Research & Development Staff
REDC Product Development and Cf Program Group
Nuclear Science and Technology Division

RECENT RELEVANT REPRESENTATIVE PUBLICATIONS

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. ”Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor for Applications in Nuclear Medicine, Oncology and Interventional Cardiology," J. Radioanalyt. Nuc. Chem., 263 (2), 503-509 (2005).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR),“ J. Label Cmpds. Radiopharm., 46 (Suppl. 1), S320(2003).

Book Chapters and Meeting Proceedings and Special Publications Describing ORNL Technology

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du., M., Klein, J. A. and Garland, M. “Direct Production of Lutetium-177 from Enriched Lu-176 in a High Flux Reactor – The Only Practical Route to Provide High Specific Activity/Multi-Curie Levels of Lu-177 Required fro Routine Clinical Use,“ For, 5th International Conference on Isotopes (5ICI), Brussels, Belgium, April 14-19, 2005 (submitted).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Isotope Reactor,” In, Proceedings, International Isotope Society Meeting, Boston, MA, June 2-6, 2003.

M. Du, F. J. Peretz; "Extraction and Purification of Th-229 for Medical Research Application", to be presented at ACS’2002 National Conference, April 10, 2002, Orlando, Florida

F. J. Peretz, J. M. Keller, M. Du; "Extraction of Th-229 from U-233 for Medical research Applications", presented at ANS National Conference, June 18, 2001, Milwaukee, Wisconsin

M. Du, C. W. Alexander; "Separation of Sm/Eu using An Extraction Chromatographic Method", presented at AIChE’2000 National Conference, March 15, 2000, Atlanta, Georgia

S. Mirzadeh, C. W. Alexander, M. Du, A. L. Beets, F. F. Knapp, Jr., G. Hirtz and R. Hobbs "Production Capabilities in the ORNL HFIR for Medical Radioisotopes", presented at AIChE’2000 Conference, March 15, 2000, Atlanta, Georgia

M. Du and G. R. Choppin; "Correlation of Equilibrium Constants with Ionic Strength by SIT, Pitzer and Parabolic Models", collected in the book of "Actinide Speciation in High Ionic Strength Media Experimental and Modeling Approaches to Predicting Actinide Speciation and Migration in the Subsurface" edited by D. T. Reed, S. B. Clark and L. Rao; Kluwer Academic/Plenum Publishers, August 1999

S. Mirzadeh, M. Du, C. W. Alexander and F.F. Knapp Jr.; "Thermochromatographic Separation of Medical Radioisotopes", presented at 216th ACS National Conference, August 23, 1998, Boston, Massachusetts

M. Du, C. W. Alexander, J. E. Bigelow, E. D. Collins; "Applications of Eichrom Columns in Processing of Radioisotopes Purification of Irradiated Strontium-89 in HCl or HNO3 media", presented at 214th ACS National Conference, September 11, 1997, Las Vegas, Nevada

C. W. Alexander, M. Du, P. A. Balo; "Production of Medical R&D Isotopes at Oak Ridge National Laboratory", presented at AIChE’97 Conference, March 11, 1997, Houston, Texas

M. Du, G.R.Choppin,"Correlation of Equilibrium Constants with Ionic Strength by SIT, Pitzer & Parabolic Models", poster presented at 212th ACS National Conference, August 26, 1996, Orlando, Florida

J. E. Bigelow, C. W. Alexander, F. F. Knapp, J. G. Tracy, M. Du, "Isotopes Beneficial Cold-War Legacy", presented at WATTec '96 Conference, February 20, 1996, Knoxville, Tennessee

Patents

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. ”High Specific Activity Platinum-195m,“ U. S. Patent No. 6,804,319, Issued October 12, 2004.

Beets, A. L., Du, M., Mirzadeh, S. and Knapp, F. F., Jr. “Method for Preparation of High Specific Activity Reactor-Produced Lutetium-177,” U.S. Patent No. 6,716,353, Issued April 5, 2004.

Mirzadeh, S., Du, M., Beets, A. L. and Knapp, F. F., Jr. “New Method for Preparation of High Specific Activity Platinum-195m for Medical Therapy,” U. S. Patent No. 6,751,280, Issued June 15, 2004.

Meeting Presentations and Published Abstracts

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L., Du, M. and Garland, M. ”Reactor Production of High Specific Activity Lutetium-177," Eur. J. Nucl. Med., 31, Suppl. 2, S387 (2004) (Poster # 455).

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Therapeutic Radioisotope Production in the High Flux Isotope Reactor (HFIR),“ 15th International Radiopharmaceutical Symposium on Radiopharmaceutical Chemistry,“ Sydney, Australia, August 10-14, 2003.

Knapp, F. F., Jr., Mirzadeh, S., Beets, A. L. and Du, M. “Production of Therapeutic Radioisotopes in the ORNL High Flux Research Reactor (HFIR),” Invited Lecture, Eighth International Symposium, The Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, Isotope Society, Boston, MA, June 1-5, 2003.


Please direct correspondence to:

Miting Du, Ph.D • Building 7965A, MS-6385 • Oak Ridge National Laboratory • Oak Ridge, TN 37831-6385 • Phone: 865-576-8095 • E-mail: dum1@ornl.gov


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