Research Areas

Curriculum Vita

Dr. Trent L. Nichols

P.O. Box 2008, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6075
Wk: (865) 574-0338, Fax: (865) 576-8993
E-mail: nicholstl@ornl.gov

Experience

Dr. Trent L. Nichols is a research engineer in the Imaging, Signals, and Machine Learning (ISML) Group at the Oak Ridge National Laboratory. He has 21 years of experience as an Internist. He earned his Doctor of Medicine from the University of Tennessee, Memphis in 1986, with a focus on Internal Medicine. In 2008 he earned his Doctor of Philosophy from the University of Tennessee, Knoxville, with a focus on Theoretical Biophysics. Since joining the ISML Group in 2009, he has been doing research in the biomedical field. He has authored and coauthored 60 publications and has been issued 3 grants in the biomedical field.

Other Pertinent Experience

Computer Analyst with Q clearance, Computer Science Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6266, 1980 to 1981

President of the Founding Board, University Physicians Association, Inc., 1993 to 1995; President, 1995 to 1998; Board Member 1993 to 1999; Medical Director, 1998 to 1999

Board Member, Bioneutrics, Inc., 9821 Cogdill Road, Suite 1, Knoxville, Tennessee 37932, 1996 to 2003

Board Member, Volunteer Research Group, 1924 Alcoa Highway, Knoxville, Tennessee 37920, 1998 to 1999

Board of Councillors, International Society for Neutron Capture Therapy, 2000 to 2006

Advanced Cardiac Life Support (ACLS) Instructor

Advanced Stroke Life Support (ASLS) Instructor

Education

Ph.D.	Theoretical Biophysics, Univeristy of Tennessee, Knoxville, Tennessee, 2008
MD.	Internal Medicine, University of Tennessee Center for the Health Sciences, Memphis, Tennessee, 1986
M.S.	Theoretical Condensed Matter Physics, University of Tennessee, Knoxville, 1978
B.S.	Enginnering Physics, University of Tennessee, Knoxville, Tennessee, 1976

Medical Licensure

Tennessee

Drug Engorcement Agency

Board Certification

National Board of Medical Examiners, 1987

American Board of Internal Medicine, 1996-2006

Current Hospital Appointments

The University of Tennessee Medical Center, Knoxville, Tennessee

Cookeville Regional Medical Center, Cookeville, Tennessee

Recent Awards

Eagle Scout 1968

National Honor Society 1971

National Merit Scholarship Honorable Mention 1972

Sigma Pi Sigma National Physics Honor Society, Chapter President 1978-1979, Chapter Vice-President 1976-1977, Chapter Secretary 1973-1976

Fellowship to the Neils Bohr Institutet Copenhagen, Denmark, 1979-1980 as a graduate student in physics to study theoretical nuclear physics

Alpha Epsilon Delta (premedical honor society), 1982 Scholarship Winner

Appointed as a student member of the Academic Affairs Committee of The University of Tennessee Board of Trustees, 1984-1985 and 1985-1986

National Institutes of Health Medical Student Research Fellow, 1984 & 1985

Board of Councilors, International Society for Neutron Capture Therapy, 2000-2006

Fellow of the American College of Physicians, 2004

Selected Publications

Trent L. Nichols, George W. Kabalka, Laurence F. Miller, Michael T. McCormack, and Andrew Johnson, “Implications for Clinical Treatment from the Micrometer Site Dosimetric Calculations in of Boron Neutron Capture Therapy”, Applied Radiation and Isotopes, 67(2009) S161-S163.

Slaybaugh, R.N.; Azmy, Y. Y.; Williams, M. L.; Langer, M. P.; Kirk, B. L.; Peplow, D. E.; Ilas, D.; and Nichols, T. L., “Radiation Treatment Planning Using Discrete Ordinates Codes”, Transactions of the American Nuclear Society, (2007), 96, pp. 343-345.

T. L. Nichols, L. F. Miller, G. W. Kabalka, and T. M. Dudney, “Microdosimetric Study for Interpretation of Outcomes from Boron Neutron Capture Therapy Clinical Trials”, Radiation Protection Dosimetry, (2007) 126(1-4): pp. 645-647.

T. L. Nichols, L. F. Miller, G. W. Kabalka, “The Microdosimetry of Boron Neutron Capture Therapy in a Randomised Ellipsoidal Cell Geometry”, Radiation Protection Dosimetry, 116, 1-4 Pt 2, pp466-469, 2005.

Kabalka, G. W.; Nichols, T. L.; Smith, G. T.; Miller, L.F.; Khan, M. K., and Busse, P. M. “The use of positron emission tomography to develop boron neutron capture therapy treatment plans for Metastatic Malignant Melanoma”, Journal of Neuro-Oncology, 62: 187-195, 2003.

Nichols, T. L.; Kabalka, G. W.; Miller, L. F.; Khan, M.; Wyatt, M.; Smith, G. T.; Longford, C.P.D. “Improved Treatment Planning for Boron Neutron Capture Therapy for Glioblastoma Multiforme Using Fluorine-18 Labelled para-Boronophenylalanine and Positron Emission Tomography”, Med. Phys., Vol. 29, Issue 10, pp2351-2358, 2002.

Kabalka, G. W.; Srivastava, R. R.; Das, B.C.; Nichols, T. L.; Smith, G. T. “The Development of Boron Neutron Capture Agents Utilizing Positron Emission Tomography,” in Contemporary Boron Chemistry, Hughes, A.K.; Davidson, M. (Eds.) Royal Society of Chemistry, Cambridge, United Kingdom, 2000, p120.

“Treatment Planning Based on Dynamic Positron Emission Tomography for Boron Neutron Capture Therapy for Glioblastoma Multiforme.”, Trent L. Nichols, George W. Kabalka, Gary T. Smith, Jon P. Dyke, C. P. D. Longford, Karl F. Hübner, Frontiers in Neutron Capture Therapy, Hawthorne, M. F. and Wiersma, R. M. (Eds), Plenum Press, New York, 1508 pages (July 1, 2001) Plenum Pub Corp; ISBN: 030646442X.

“The Role of Dynamic Positron Emission Tomography for Quantifying Boron-10 InVivo Using the Fructose Complex F-18 Labeled Boronophenylalanine PET”. G. W. Kabalka, G. T. Smith, T. L. Nichols, J. P. Dyke, D. Longford, and K. F. Hübner, Frontiers in Neutron Capture Therapy, Hawthorne, M. F. And Wiersma, R. M. (Eds), Plenum Press, New York, 1508 pages (July 1, 2001), Plenum Pub Corp; ISBN: 030646442X.

“The Use of Positron Emission Tomography in Treatment Planning for Boron Neutron Capture Therapy: A Clinical Perspective.”, T. L. Nichols, G. W. Kabalka, G. T. Smith, D. Longford, E. Buonocore, and K. F. Hübner, Clinical Physiology, p255, 18:3, 1998.

“Determination of Cardiac Equivalent Generator Properties Using a Numerical Expansion Method”, T. L. Nichols, M. A. Lawson, and D. M. Mirvis, Journal of Electrocardiology 20(5), pp. 352-356, 1987.

“Frequency Content of the Electrocardiogram. Spatial Features and Effects of Myocardial Infarction”, T. L. Nichols and D. M. Mirvis, Journal of Electrocardiology 18(2), 1985, pp. 185-194.

“Heavy-Ion Transfer Reactions as a Unique Probe of Quantal Many-Body Systems”, M. W. Guidry and T. L. Nichols, Phys. Rev. C., 25(1), 1982, pp.689-692.

“Inelastic Scattering and Transfer Reactions using very Heavy Ions”, M. W. Guidry, R. E. Neese, and T. L. Nichols, Contemporary Research in Nuclear Physics, (Plenum Press, 1982), pp. 193-222.

“Heavy-Ion Two-Neutron Transfer Reactions in Deformed Nuclei”, M. W. Guidry, T. L. Nichols, R. E. Neese, J. O. Rasmussen, L. Oliviera, R. Donangelo, and D. Habs, Invited Paper for the Sven Gosta Nilsson Memorial Issue, Nuc. Phys., A361, 275 (1981).

“Anisotropic Effects in Dilute Pt-Mn: A Nuclear Orientation Study”, J. R. Thompson, J. O. Thomson, P. G. Huray, S. E. Nave, and T. L. Nichols, J. Phys. F: Metal Phy., 8, No. 1 (1978).