Jennifer Morrell-Falvey

Jennifer Morrell-Falvey

Biological and Nanoscale Systems
BioSciences Division
Oak Ridge National Laboratory
Oak Ridge, TN 37831-6445
Phone: (865) 241-2841
Fax: (865) 574-5345
morrelljl1@ornl.gov

Jennifer Morrell-Falvey received her Ph.D. in Genetics from Purdue University in 1997.  During her graduate and post-graduate work, she studied the molecular mechanisms and regulation of cell division in fungal systems using a combination of genetic, molecular, biochemical, and imaging techniques.  Jennifer joined the staff of Oak Ridge National Laboratory in 2004 and is currently a scientist in the Biological and Nanoscale Sciences group.  Her research focuses on using imaging techniques to investigate biological systems at multiple scales, from macromolecular interactions and cellular signaling to community structure.  A main topic of her recent work is investigating plant-microbe interactions using molecular genetics, live cell imaging methods, and super resolution microscopy. Current projects involve investigation of microbial colonization of Poplar roots, and cellulose attachment and degradation by thermophilic bacteria for biofuel production. 

Selected Publications

  1. Weston, D. J., Pelletier, D.A., Morrell-Falvey, J.L., Tschaplinski, T.J., Jawdy, S.S., Lu,T.S., Allen, S.M., Melton, S.J., Martin, M.Z., Schadt, C.W., Karve, A.A.,  Chen, J-G., Yang, X., Doktycz, M.J., and Tuskan, G.A. (2012). “Pseudomonas fluorescens Induces Strain-Dependent and Strain-Independent Host Plant Responses in Defense Networks, Primary Metabolism, Photosynthesis, and Fitness”. MPMI 25(5), 765-78
  2. Feoktistova, A., Morrell-Falvey, J.L., Chen, J., Singh, N.S., Balasubramanian, M.B., Gould, K.L.  (2012).  “The fission yeast SIN kinase, Sid2, is required for SIN asymmetry and regulates the SIN scaffold, Cdc11”. Mol. Biol. Cell 23(9), 1636-45.
  3. Suresh, A.K, Pelletier, D.A., Wang, W., Morrell-Falvey, J.L., Gu, B., Doktycz, M.J. (2012).  “Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types”. Langmuir 28 (5), 2727-2735.
  4. Wang, Z., Lee, S., Elkins, J.G., and Morrell-Falvey, J.L. (2011) “Spatial and Temporal dynamics of biofilm formation and cellulose degradation by Caldicellulosiruptor obsidiansis and Clostridium thermocellum”. AMB Express 1:30.
  5. Wang, Z., Hamilton-Brehm, S.D., Lochner, A., Elkins, J.G., and Morrell-Falvey, J.L. (2011) “Mathematical modeling of hydrolysate diffusion and utilization in cellulolytic biofilms of the extreme thermophile Caldicellulosiruptor obsidiansis”  Bioresource Tech 102, 3155-3162.
  6. Edwards, A.E., Siuti, P., Bible, A.N., Alexandre, G., Retterer, S.T., Doktycz, M.J., Morrell-Falvey, J.L. (2011) “Characterization of Cell Surface and EPS Remodeling of Azospirillum brasilense Chemotaxis-like 1 Signal Transduction Pathway mutants by Atomic Force Microscopy” FEMS Micro Lett 314 (2), 131-139.
  7. Borole, A.P., Hamilton, C.Y., Vishnivetskaya,T.A., Leak, D., Andras, C., Morrell-Falvey, J.L.,  Keller, M., Davison, B. (2009) “Integrating Engineering Design Improvements with Exoelectrogen Enrichment Process to Increase Power Output from Microbial Fuel Cells”  J. Power Sources 191(2), 520-527.
  8. Edwards, A.N., Fowlkes, J.D., Standaert, R.F., Pelletier, D.A., Doktycz, M.J., Morrell-Falvey, J.L. (2009) “An in vivo imaging-based assay for detecting protein interactions over a wide range of binding affinities.” Analyt. Biochem 395(2), 166-177.
  9. Hervey, W.J. 4th, Khalsa-Moyers,G., Lankford, P.K., Owens, E.T., McKeown, C.K., Lu, T.Y, Foote, L.J., Asano,K.G., Morrell-Falvey, J.L., McDonald, W.H., Pelletier, D.A., Hurst, G.B. (2009) “Evaluation of Affinity-Tagged Protein Expression Strategies using Local and Global Isotope Ratio Measurements” Analyt. Chem, 8(7), 3675-3688.
  10. Pelletier, D.A., Hurst, G.B., Foote, L.J., Lankford, P.K., McKeown, C.K., Lu, T.Y., Schmoyer, D.D., Shah, M.B., Hervey, W.J. 4th, McDonald, W.H., Hooker, B.S., Cannon, W.R., Daly, D.S., Gilmore, J.M., Wiley, H.S., Auberry, D.L., Wang, Y., Larimer, F.W., Kennel, S.J., Doktycz, M.J., Morrell-Falvey, J.L., Owens, E.T., Buchanan, M.V. (2008) “A general system for studying protein-protein interactions in Gram-negative bacteria.” J Proteome Res. 7(8), 3319-28.
  11. Venkataraman, S., Doktycz, M. J., Qi, H., and Morrell-Falvey, J. L. Automated analysis of fluorescence microscopy images to identify protein-protein interactions.  International Journal of Biomedical Imaging vol. 2006, Article ID 69851, 10 pages, 2006.
  12. Venkataraman, S., Allison, D.P., Qi, H., Morrell-Falvey, J.L., Kallewaard, N.L., Crowe, J.E., Doktycz, M.J. 2006. Automated image analysis of atomic force microscopy images of rotavirus particles. Ultramicroscopy 106:829-837
  13. Beckmann, M. A., Venkataraman, S., Doktycz, M. J., Nataro, J. P., Sullivan, C.J., Morrell-Falvey, J.L., Allison, D.P. 2006. Measuring cell surface elasticity on enteroaggregative Escherichia coli wild type and dispersin mutant by AFM. Ultramicroscopy 106:695-702
  14. Chourey, K., Thompson, M.R., Morrell-Falvey, J.L., Verberkmoes, N.C., Brown, S. D., Shah, M., Zhou, J., Doktycz, M., Hettich, R. L., Thompson, D.K.  2006. Global molecular and morphological effects of 24-hour chromium (VI) exposure on Shewanella oneidensis MR-1. Appl Environ Microbiol. 72(9):6331-44.
  15. Morrell-Falvey, J.L., Ren, L., Feoktistova, A., Den Haese, G.,  Gould, K.L. 2005. Cell wall remodeling at the fission yeast division site requires the Rho-GEF, Rgs3p.  J. Cell Sci.118:5563-5573
  16. Sullivan, C.J., Morrell, J.L., Allison, D.P., Doktycz, M.J. 2005.  AFM mounting and imaging of Escherichia coli spheroplasts.  Ultramicroscopy 105:96-102. 
  17. Martin-Cuadrado, A.B., Morrell, J.L., Konomi, M., An, H., Petit, C., Osumi, M., Balasubramanian, M., Gould, K.L., del Ray, F., Vazquez de Aldana, C.R.  2005. Role of septins and the exocyst complex in the function of hydrolytic enzymes responsible for fission yeast cell separation.  Mol. Biol. Cell 16:4867-4881.
  18. Ren, L., Feoktistova, A., McDonald, W.H., Den Haese, G., Morrell, J.L., Gould. K.L. Analysis of the role of phosphorylation in fission yeast Cdc13p/Cyclin B function. J. Biol. Chem. 280(15):14591-6.
  19. Fletcher, B.L., Hullander, E.D., Melechko, A.V., McKnight, T.E., Klein, K.L, Hensley, D.K., Morrell, J.L., Simpson, M.L., Doktycz, M.J. 2004. Microarrays of biomimetic cells formed by the controlled synthesis of carbon nanofiber membranes. Nano Lett. 4(10): 1809-1814.
  20. Morrell, J.L., Nichols, C.B., Gould, K.L.  2004. The GIN4 family kinase, Cdr2p, acts independently of septins in fission yeast.  J. Cell Sci. 117(22):5293-5302.
  21. An, H., Morrell, J.L., Tasto, J.J., Jennings,J.L., Link, A.J.,  Gould, K.L. 2004.  Interdependence of S. pombe septins for complex formation, localization and function. Mol. Biol. Cell. 15(12):5551-5564
  22. Morrell, J.L., Tomlin, G.C., Rajagopalan, S., Venkatram, S., Tasto, J.J., Mehta, S., Jennings, J.L., Link, A.J., Balasubramanian, M.K., Gould, K.L. 2004. Sid4p-Cdc11p assemble the septation initiation network and its regulators at the S. pombe SPB. Curr Biol 14(7):579-584.
  23. Tasto, J.J., Morrell, J.L., Gould, K.L. 2003.  Anillin-related Mid2p acts during fission yeast cytokinesis to organize the septin ring and promote cell separation. J.Cell Biol. 160(7):1093-1103.
  24. Schadick, K, H., Fourcade, M., Boumenot, P., Seitz, J.J., Morrell, J.L. Chang, L., Gould, K.L., Partridge, J.F., Allshire, R.C., Kitagawa, K., Hieter, P., Hoffman, C.S.. 2002 Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae Sgt1p family, is required for glucose and cyclic AMP signaling, cell wall integrity, and septation. Eukaryot. Cell. 1(4):558-67
  25. Tomlin, G.T., Morrell, J.L., Gould, K.L. 2002.  The spindle pole body protein Cdc11p links Sid4p to the fission yeast septation initiation network.  Mol. Biol. Cell. 13 (4): 1203-1214.
  26. Bruno, K.S., Morrell, J.L., Hamer, J.E., Staiger, C.J. 2001. SEPH, a Cdc7p orthologue from Aspergillus nidulans, functions upstream of actin ring formation during cytokinesis.  Mol. Microbiol. 42:3-12.
  27. Chang, L., Morrell, J.L., Feokstitova, A., Gould, K.L.  2001. Study of cyclin proteolysis in anaphase promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network.  Mol. Cell. Biol. 21:6681-6694
  28. Morrell, J.L., Morphew, M., Gould, K.L. 1999.  A mutant of Arp2p causes partial disassembly of the Arp2/3 complex and loss of cortical actin function in fission yeast. Mol. Biol. Cell 10:4201-4215.
  29. Momany, M., Morrell, J.L., Harris, S.D., Hamer, J. E. 1995.  Septum formation in Aspergillus nidulans. Canadian J. of Bot. 73(Supp. 1):S396-S399.
  30. Harris, S. D., Morrell, J. L., Hamer, J. E. 1994.  Identification and characterization of Aspergillus nidulans mutants defective in cytokinesis. Genetics 136:517-532.