Poster Presentation 1B-23

A Study on Chemo-Enzymatic Synthesis of Sorbitan Methacrylate

Ki-Young Byun,^1,3 Don-Hee Park,^1,2,3* Changshin Sunwoo,^1,2 Min Su Ryu,^1,2,

Sung-Hyo Chough,¹ Woo-Tai Lee,¹ Hea-Sung Kim,⁴ Yung-il Joe,⁵

In-Heung Kim⁶ and Kwang-Youn Lee⁷

¹Faculty of Applied Chemical Engineering

²School of Biological Sciences and Technology

³Research Institute for Catalysis

Chonnam National University,

Kwangju 500-757, KOREA

Phone: +82-62-530-1841

Fax: +82-62-530-1849

E-mail: dhpark@chonnam.ac.kr

⁴Dept. of Chemical Engineering, Myongji University, Yongin 449-728, Korea

⁵Dept. of Chemical Engineering, Yonsei University, Seoul 120-749, Korea

⁶Daehan Vaccum Co. Ltd., Seoul 133-120, Korea

⁷Dept. of Opthalmic Optics, Dong-A College, Chonnam 526-872 , Korea

Biomaterials are a generic term which is widely utilized as a medical purpose in direct contact with living tissue. That is the reason why it must be carefully and microscopically fabricated to best adjust the living organism in both functional and structural sense. It is also used as a essential material in manufacturing the catheter, contact lens and artificial human heart. Recently, it is reported that even a drug-delivery system in human body could be developed by means of biomaterials. Medical devices are another example of biomaterialistic invention.

The experiment was performed to observe the synthetic reaction of 1,4-sorbitan and methacrylate when manipulated by immobilized biocatalyst Novozyme 435. As a conclusion, 55.58% of sorbitan methacrylate showed transformation when 1,4-sorbitan and methacrylate were synthesized by 1 to 3 molar ratio under experimental situation. The experimental conditions were as follows:

-The temperature was 50 ^◦C.

-Biocatalyst 1% (w/v) of Novozyme 435 was used.

-1.25 cm magnetic bar stirrer was used to produce 300 rpm speed.

- The reaction was carried out for 40 hours.