Biosciences Division

News

  • New ORNL process brings nanoparticles into focus

    Scientists can study the biological impacts of engineered nanomaterials on cells within the body with greater resolution than ever because of a procedure developed by researchers at the Department of Energy's Oak Ridge National Laboratory.

  • Audio Spot: New medicine therapeutics company is spinout from ORNL

    A Company, NellOne Therapeutics, has been formed through Battelle Ventures to research the potential for a new therapy that could help heart patients, according to Oak Ridge National Laboratory scientist Cymbeline Culiat.

2005 Publications

Adams, J. D., B. Rogers, L. Manning, Z. Hu, T. Thundat, H. Cavazos, and S. C. Minne, “Piezoelectric self-sensing of adsorption-induced microcantilever bending,” Sensors and Actuators A-Physical 121(2): 457-461 (June 2005).

Barnes, M. D., A. Mehta, P. Kumar, B. G. Sumpter, and D. W. Noid, “Confinement effects on the structure and dynamics of polymer systems from the mesoscale to the nanoscale,” Journal of Polymer Science Part B – Polymer Physics 43(13): 1571-1590 (July 2005).

Barnes, M. D., P. S. Krstic, P. Kumar, A. Mehta, and J. Wells, “Far-field modulation of fluorescence decay rates in pairs of oriented semiconducting polymer nanostructures,” Physical Review B 71(24): Art. No. 241303 (June 2005).

Blishchenko, E. Y., O. V. Sazonovz, O. A. Kalinina, E. V. Moiseeva, A. A. Vass, A. A. Kerelin, and V. T. Ivanova, “Anti-tumor effect of valorphin in vitro and in vivo – Combined action with cytostatic drugs,” Cancer Biology & Therapy 4(1): 118-124 (January 2005).

Boiadjiev, V.I., G. M. Brown, L. A. Pinnaduwage, G. Goretzki, P. V. Bonnesen, T. Thundat, “Photochemcial hydrosilylation of 11-undecenyltriethylammonium bromide with hydrogen-terminated Si surfaces for the development of robust microcantilever sensors for Cr (VI),” Langmuir 21(4): 1139-1142 (February 2005).

Chick, W. S. H., S. E. Mentzer, D. A. Carpenter, E. M Rinchik, D. Johnson, and Y. You, “X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15,” Mammalian Genome 16(9): 661-671 (September 2005).

Cho, H. P., Y. Liu, M. Gomez, J. Dunlap, M. Tyers, and Y. S. Wang, “The dual-specificity phosphatase CDC14B bundles and stabilizes microtubles,” Molecular and Cellular Biology 25(11): 4541-4551 (June 2005).

Culiat, C. T., M. L. Klebig, Z. W. Liu, H. Monroe, B. Stanford, J. Desai, S. Tandan, L. Hughes, M. K. Kerley, D. A. Carpenter, D. K. Johnson, E. M. Rinchik, and Q. B. Li, “Identification of mutations from phenotype-driven ENU mutagenesis in mouse Chromosome 7,” Mammalian Genome 16(8): 555-566 (August 2005).

Dareing, D. W. and T. Thundat, “Simulation of adsorption-induced stress of a microcantilever sensor,” Journal of Applied Physics 97 (4): Art. No. 043526 (February 2005).

Dareing, D. W. and T. Thundat, “Mighty mites,” Mechanical Engineering 127(9): 34-37 (September 2005).

Dareing, D. W., T. Thundat, S. M. Jeon, and M. Nicholson, “Modal analysis of microcantilever sensors with environmental damping,” Journal of Applied Physics 97(8): Art. No. 084902 (April 2005).

Ding, F., Y. Prints, M. S. Dhar, D. K. Johnson, C. Garnacho-Montero, R. D. Nicholls, and U. Francke, “Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models,” Mammalian Genome 16(6): 424-431 (June 2005).

Feil, J., W. S. Feil, P. Chain, F. Larimer, G. DiBartolo, A. Copeland, A. Lykidis, S. Trong, M. Nolan, E. Goltsman, J. Thiel, S. Malfatti, J. E. Loper, A. Lapidus, J. C. Detter, M. Land, P. M. Richardson, N. C. Kyrpides, N. Ivanova, and S. E. Lindow, “Comparison of the complete genome sequences of Pseudomonas syringae pv. Syringae B728a and pv. tomato DC3000,” Proceedings of the National Academy of Sciences of the United States of America 102(31): 11064-11069 (August 2005).

Goldowitz, D., W. N. Frankel, J. S. Takahasi, M. Holtz-Vitaterna, C. Bult, W. A. Kibbe, J. Snoddy, Y. X. Li, S. Pretel, J. Yates, and D. J. Swanson, “Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function,” Molecular Brain Research 132(2): 105-115 (December 2004).

Hu, Z. Y., V. Boiadjiev, and T. Thundat, “Nanocatalytic spontaneous ignition and self-supporting room-temperature combustion,” Energy & Fuels 19(3): 855-858 (May – June, 2005).

Huang, B., L. J. Foote, T. K. Langford, S. M. Davern, C. K. McKeown, and S. J. Kennel, “A diabody that dissociates to monomer forms at low concentration: effects on binding activity and tumor targeting,” Biochem. and Biophys. Res. Comm., 327(4): 999-1005 (February 2005).

Ji, H. F., X. D. Yan, J. Zhang, and T. Thundat, “Molecular recognition of biowarfare agents using micromechanical sensors,” Expert Review of Molecular Diagnostics 4(6): 859-866 (November 2004).

Kalinin, S. V., B. J. Rodriguez, S. Jesse, T. Thundat, and A. Gruverman, “Electromechanical imaging of biological systems with sub-10 nm resolution,” Applied Physics Letters 87(5): Art. No. 053901 (August 2005).

Karim, K., K. T. Klasson, R. Hoffmann, S. R. Drescher, D. W. DePaoli, and M. H> Al-Dahhan, “Anaerobic digestion of animal waste: Effect of mixing", Bioresource Technology 96(14): 1607-1612 (September 2005).

Karim, K., R. Hoffman, T. Klasson, and M. H. Al-Dahhan, “Anaerobic digestion of animal waste: Waste strength versus impact of mixing," Bioresource Technology 96(16): 1771-1781 (November 2005).

Khokhryakov, V. F., K. G. Suslova, V. V. Vostrotin, S. A. Romanov, K. F. Eckerman, M. P. Krahenbuhl, and S. C. Miller, “Adaptation of the ICRP Publication 66 Respiratory Tract Model to data on plutonium biokenetics for Mayak workers,” Health Physics 88(2): 125-132 (February 2005).

Kirov, S. A., X. Peng, E. Baker, D. Schmoyer, B. Zhang, and J. Snoddy, “GeneKeyDB: A lightweight, gene-centric, relational database to support data mining environments,” BMC Bioinformatics 6: Art. No. 72 (March 2005).

Kohen, R., S. Kirov, G. P. Navaja, H. K. Happe, M. W. Hamblin, J. R. Snoddy, J. F. Neumaier, and F. Petty, “Gene expression profiling in the hippocampus of learned helpless and nonhelpless rats,” Phamacogenomics Journal 5(5): 278-291(October 2005).

Kolker, E., A. F. Picone, M. Y. Galperin, M. F. Romine, R. Higdon, K. S. Makarova, N. Kolker, G. A. Anderson, X. Y. Qiu, K. J. Auberry, G. Babnigg, A. S. Beliaev, P. Edlefsen, D. A. Elias, Y. A. Gorby, T. Holzman, J. A. Klappenbach, K. T. Konstantinidis, M. L. Land, M. S. Lipton, L. A. McCue, M. Monroe, L. Pasa-Tolic, G. Pinchuk, S;. Purvine, M. H. Serres, S. Tsapin, B. A. Zakrajsek, J. H. Zhou, F. W. Larimer, C. E. Lawrence, M. Riley, F. R. Collart, J. R. Yates, R. D. Smith, C. S. Giometti, K. H. Nealson, J. K. Fredrickson, J. M. Tiedje, “Global profiling of Shewanella oneidensis MR-1: Expression of hypothetical genes and improved functional annotations,” Proceedings of the National Academy of Sciences of the United States of America 102(6): 2099-2104 (February 2005).

Kuritz, T., I. Lee, E. T. Owens, M. Humayun, and E. Greenbaum, “Molecular photovoltaics and the photoactivation of mammalian cells,” IEEE Transactions on NanoBioscience 4(2): 196-200 (June 2005).

Leggett, R. W., K. E. Eckerman, V. E. Khokhryakov, K. G. Suslova, M. P. Krahenbuhl, and S. C. Miller, “Mayak worker study: An improved doses from internally biokenetic model for reconstructing deposited plutonium,” Radiation Research 164(2): 111-122 (August 2005).

Lereu, A. L., A. Passian, J. P. Goudonnet, T. Thundat, and T. L. Ferrell, “Optical modulation processes in thin films based on thermal effects of surface plasmons,” Applied Physics Letter 86(15): Art. No. 154101 (April 2005).

Lin, H. H., D. E. Faunce, M. Stacey, A. Terajewicz, T. Nakamura, J. Zhang-Hoover, M. Kerley, M. L. Mucenski, S. Gordon, and J. Stein-Streilein, “ The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance,” Journal of Experimental Medicine 201(10): 1615-1625 (May 2005).

Opresko, D. M., “A new species of antipatharian coral (Cnidaria : Anthozoa: Antipatharia) from the southern California Bight,” Zootaxa (852): 1-10 (February 2005).

Oren, A., F. Larimer, P. Richardson, A. Lapidus, and L. N. Csonka, “How to be moderately halophilic with broad salt tolerance: clues from the genome of Chromohalobacter salexigens,” Extremophiles 9(4): 275-279 (August 2005).

Pan, C. and R. L. Hettich, “Multipole-storage-assisted dissociation for the characterization of large proteins and simple protein mixtures by ESI-FTICR-MS,” Analytical Chemistry 77(10): 3072-3082 (May 2005).

Passian, A., R. H. Ritchie, A.L. Lereu, T. Thundat, and T. L. Ferrell, “Curvature effects in surface plasmon dispersion and coupling,” Physical Review 71(11): Art. No. 115425 (March 2005).

Passian, A., A. L. Lereu, A. Wig, F. Meriaudeau, T. Thundat, and T. L. Ferrell, “Imaging standing surface plasmons by photon tunneling,” Physical Review 71(16): Art. No. 165418 (April 2005).

Pinnaduwage, L. A., H. F. Ji, and T. Thundat, “Moore’s law in homeland defense: An integrated sensor platform based on silicon microcantilevers,” IEEE Sensors Journal 5(4): 774-785 (August 2005).

Ram, R. J., N. C. VerBerkmoes, M. P. Thelen, G. W. Tyson, B. J. Baker, R. C. Blake, M. Shah, R. L. Hettich, and J. F. Banfield, “Community proteomics of a natural microbial biofilm,” Science 308(5730): 1915-1920 (June 2005).

Russell, L. B., P. R. Hunsicker, M. Kerley, A. Pyle, and A. M. Saxton, “Etoposide exposure during male mouse pachytene has complex effects on crossing-over and causes nondisjunction,” Mutation Research-Genetic Toxicology and Environ. Mutagenesis 565(1): 61-77 (December 2004).

Sharp, J. S., J. T. Guo, T. Uchiki, Y. Xu, C. Dealwis, and R. L. Hettich, “Photochemical surface mapping of C14S-Sml1p for constrained computational modeling of protein structure,” Analytical Biochemistry 340(2): 201-212 (May 2005).

Song, J. M., M. Culha, P. A. Kasili, G. D. Griffin, and T. Vo-Dinh, “A compact CMOS biochip immunosensor towards the detection of a single bacteria,” Biosensors & Bioelectronics 20(11): 2203-2209 (May 2005).

Squibb, K. S., R. W. Leggett, and M. A. McDiarmid, “Prediction of renal concentrations of depleted uranium and radiation dose in Gulf War veterans with embedded shrapnel,” Health Physics 89(3): 367-273 (September 2005).

Tabb, D. L., C. Narasimhan, M. B. Strader, and R. L. Hettich, “DBDigger: Reorganized proteomic database identification that improves flexibility and speed,” Analytical Chemistry 77(8): 2464-2474 (April 2005).

Tabb, D. L., M. R. Thompson, G. Khalsa-Moyers, N. C. VerBerkmoes, and W. H. McDonald, “MS2Grouper: Group assessment and synthetic replacement of duplicate proteomic tandem mass spectra,” Journal of the American Society for Mass Spectrometry 16(8): 1250-1261 (August 2005).

Thyrell, L., O. Sangfelt, B. Zhivotovsky, K. Pokrovskaja, Y. S. Wang, S. Einhorn, and D. Grander, “The HPV-16 E7 oncogene sensitizes malignant cells to IFN-alpha-induced apoptosis,” Journal of Interferon and Cytokine Research 25(2): 63-72 (February 2005).

Tian, F., K. M. Hansen, T. L. Ferrell, and T. Thundat, “Dynamic microcantilever sensors for discerning biomolecular interactions,” Analytical Chemistry 77(6): 1601-1606 (March 2005).

Tian, F., V.I. Boiadjiev, L. A. Pinnaduwage, G. M. Brown, and T. Thundat, “Selective detection of Cr(VI) using a microcantilever electrode coated with a self-assembled monolayer,” Journal of Vacuum Science & Technology A 23(4): 1022-1028(July-August 2005).

Vo-Dinh, T. and P. Kasili, “Fiber-optic nanosensors for single-cell monitoring,” Analytical and Bioanalytical Chemistry 382(4): 918-925 (June 2005).

Vo-Dinh, T., F. Yan, and M. B. Wabuyele, “Surface-enhanced Raman scattering for medical diagnostics and biological imaging,” Journal of Raman Spectroscopy 36 (6-7): 640-647 (June – July 2005).

Volkan, M., D. L. Stokes, and T. Vo-Dinh, “A sol-gel derived AgCl photochromic coating on glass for SERS chemical sensor application,” Sensors and Actuators B-Chemical 106(2): 660-667 (May 2005).

Wabuyele, M. B., F. Yan, G. D. Griffin, and T. Vo-Dinh, “Hyperspectral surface-enhanced Raman imaging of labeled silver nanoparticles in single cells,” Review of Scientific Instruments 76(6): Art. No. 063710 (June 2005).

Wan, X. F., N. C. VerBerkmoes, L. A. McCue, D. Stanek, H. Connelly, L. J. Hauser, L. Y. Wu, X. D. Liu, T. F. Yan, A. Leaphart, R. L. Hettich, J. Z. Zhou, and D. K. Thompson, “Transcriptomic and proteomic characterization of the fur modulon in the metal-reducing bacterium Shewanella oneidensis,” Journal of Bacteriology 186(24): 8385-8400 (December 2004).

Wang, Y. S., N. Erdmann, R. J. Giannone, J. Wu, M. Gomez, and Y. Liu, “An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres,“ Proceedings of the National Academy of Sciences 102(29): 10256-10260 (July 2005).

Yan, F., M. B. Wabuyele, G. D. Griffin, A. A. Vass, and T. Vo-Dinh, “Surface-enhanced Ramam scattering, detection of chemical and biological agent stimulants,” IEEE Sensors Journal 5(4): 665-670 (August 2005).

Yan, F., S. Williams, G. D. Griffin, R. Jagannathan, S. E Plunkett, K. H. Shafer, and T. Vo-Dinh, “Near-real-time determination of hydrogen peroxide generated from cigarette smoke,” Journal of Environmental Monitoring 7(7): 681-687 (July 2005).

Zhang, B.,S. Kirov, and J. Snoddy, “WebGestalt: an integrated system for exploring gene sets in various biological contexts,” Nucleic Acids Research 33: W741-W748 Suppl. 2 (July 2005).

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