Phone: (865)-574-2631

standaertrf@ornl.gov

Bob Standaert is a Staff Scientist in the Life Sciences Division at the Oak Ridge National Laboratory. He received his A.B. in chemistry in 1985 from Cornell University, his S.M. in chemistry from Yale University in 1988, and his Ph.D. in Chemistry from Harvard University in 1992. From 1992–1995, he was a Merck post-doctoral fellow at Harvard in the laboratory of Prof. Stuart L. Schreiber, and prior to joining the staff at ORNL, he was an assistant professor of chemistry at Texas A&M (1995–2001) and an associate professor of chemistry at the University of Illinois at Chicago (2001–2005). His research interests, broadly described, involve applications of organic chemistry to biological problems. Current projects involve primarily the development of light-responsive molecules to mediate biological responses and materials recognition.

1. Fontes, M. R. M., Teh, T., Riell, R. D., Park, S. B., Standaert, R. F., Kobe, B. (2005) "Crystallization and preliminary X-ray diffraction analysis of importin-? complexed with NLS peptidomimetics" Biochim. Biophys. Acta, 1750, 9–13.

2. Vu, T. Q., Chowdhury, S., Muni, N. J., Qian, H., Standaert, R. F., Pepperberg, D. R. (2005) "Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment" Biomaterials, 26, 1895–903.

3. Jayathilaka, L. P., Deb, M., Standaert, R. F. (2004) "Asymmetric synthesis and translational competence of L-?-(1-cyclobutenyl)glycine" Org. Lett., 6, 3659–62.

5. Park, S. B., Ho, T. H., Reedy, B. M., Connolly, M. D., Standaert, R. F. (2003) "Simple mimetics of a nuclear localization signal (NLS)" Org. Lett., 5, 2437–2440.

6. Park, S. B., Standaert, R. F. (2001) "A photoregulated ligand for the nuclear import receptor karyopherin ?" Bioorg. Med. Chem., 9, 3215–23.

7. Connolly, M. D., Park, S. B., Reedy, B. M., Standaert, R. F. (2000) "A simple, solid-phase binding assay for the nuclear import receptor karyopherin ?. Part 1: direct binding" Bioorg. Med. Chem. Lett., 10, 951–4.

8. Kopytek, S. J., Standaert, R. F., Dyer, J. C., Hu, J. C. (2000) "Chemically induced dimerization of dihydrofolate reductase by a homobifunctional dimer of methotrexate" Chem. Biol., 7, 313–21.

9. Park, S. B., Reedy, B. M., Standaert, R. F. (2000) "A simple, solid-phase binding assay for the nuclear import receptor karyopherin ?. Part 2: competitive binding" Bioorg. Med. Chem. Lett., 10, 955–6.

10. VanBrunt, M. P., Standaert, R. F. (2000) "A short total synthesis of (+)-furanomycin" Org. Lett., 2, 705–8.

11. Park, S. B., Standaert, R. F. (1999) "?,?-Difluorophosphonomethyl azobenzene derivatives as photoregulated phosphoamino acid analogs. Part 1: design and synthesis" Tetrahedron Lett., 40, 6557–6560.

12. Fenteany, G., Standaert, R. F., Lane, W. S., Choi, S., Corey, E. J., Schreiber, S. L. (1995) "Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin" Science, 268, 726–31.

13. Fenteany, G., Standaert, R. F., Reichard, G. A., Corey, E. J., Schreiber, S. L. (1994) "A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line" Proc. Natl. Acad. Sci. U.S.A., 91, 3358–62.

14. Van Duyne, G. D., Standaert, R. F., Karplus, P. A., Schreiber, S. L., Clardy, J. (1993) "Atomic structures of the human immunophilin FKBP-12 complexes with FK506 and rapamycin" J. Mol. Biol., 229, 105–24.

15. Galat, A., Lane, W. S., Standaert, R. F., Schreiber, S. L. (1992) "A rapamycin-selective 25-kDa immunophilin" Biochemistry, 31, 2427–34.

16. Fretz, H., Albers, M. W., Galat, A., Standaert, R. F., Lane, W. S., Burakoff, A. J., Crabtree, G., Schreiber, S. L. (1991) "Rapamycin and FK506 binding proteins (immunophilins)" J. Am. Chem. Soc., 113, 1409–1411.

17. Van Duyne, G. D., F., S. R., Schreiber, S. L., Clardy, J. (1991) "Atomic structure of the rapamycin human immunophilin FKBP-12 Complex" J. Am. Chem. Soc., 113, 7433–7434.

18. Van Duyne, G. D., Standaert, R. F., Karplus, P. A., Schreiber, S. L., Clardy, J. (1991) "Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex" Science, 252, 839–42.

19. Bierer, B. E., Mattila, P. S., Standaert, R. F., Herzenberg, L. A., Burakoff, S. J., Crabtree, G., Schreiber, S. L. (1990) "Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin" Proc. Natl. Acad. Sci. U.S.A., 87, 9231–5.

20. Rosen, M. K., Standaert, R. F., Galat, A., Nakatsuka, M., Schreiber, S. L. (1990) "Inhibition of FKBP rotamase activity by immunosuppressant FK506: twisted amide surrogate" Science, 248, 863–6.

21. Standaert, R. F., Galat, A., Verdine, G. L., Schreiber, S. L. (1990) "Molecular cloning and overexpression of the human FK506-binding protein FKBP" Nature, 346, 671–4.

Patents / Patent Applications

1. Schreiber, S. L., Standaert, R. F., Fenteany, G., and Jamison, T. F. (1996). Lactacystin analogs for inhibition of proteasomes and treatment of proteasome-mediated diseases. PCT Int. Appl., WO 9632105 A1.

2. Fenteany, G., Jamison, T. F., Schreiber, S. L., Standaert, R. F. (1998) "Lactacystin analogs", U.S. Patent 5,756,764.

3. Fenteany, G., Jamison, T. F., Schreiber, S. L., Standaert, R. F. (2000) "Lactacystin analogs", U.S. Patent 6,147,223.

4. Fenteany, G., Jamison, T. F., Schreiber, S. L., Standaert, R. F. (2001) "Lactacystin analogs", U.S. Patent 6,214,862.

5. Fenteany, G., Jamison, T. F., Schreiber, S. L., Standaert, R. F. (2002) "Lactacystin analogs", U.S. Patent 6,335,358.

6. Fenteany, G., Jamison, T. F., Schreiber, S. L., Standaert, R. F. (2002) "Lactacystin analogs", U.S. Patent 6,458,825.

7. Schreiber, S. L., Standaert, R. F., Fenteany, G., Jamison, T. F. (2003) "Lactacystin analogs", U.S. Patent 6,645,999.

8. Schreiber, S. L., Standaert, R. F., Fenteany, G., Jamison, T. F. (2005) "Lactacystin analogs", U.S. Patent 6,838,477.