Oral Program

7:00 - 9:00 Registration
9:00 - 10:45 Plenary Session (Session 1) Chairs: Michael Paulus (ORNL), Michael Green (NIH)
9:00	Welcome and Introduction
9:15	Plenary Presentation #1: Of Mice and Men (Weissleder) Ralph Weissleder Harvard Medical School Telephone: (617) 726-8226
10:00	Plenary Presentation #2: Modeling Cancer in Mice (DePinho) Ron DePinho Harvard Medical School Telephone (617) 632-6085
10:45 - 11:00 Morning Break
11:00 - 12:40 Invited Presentations (Session 2) Chairs: Simon Cherry (UC Davis), Stuart Foster (University of Toronto)
11:00	Invited Presentation #1: Recent Developments in MRI Imaging of Small Animals (Balaban) Robert Balaban National Institutes of Health Telephone: (301) 496-3658
11:20	Invited Presentation #2: What We Can Learn About Biology Through In Vivo Bioluminescent Imaging (Contag) Christopher Contag Stanford University Telephone: (650) 725-8781
11:40	Invited Presentation #3: Recent Advances in Molecular Imaging (Gambhir) Sam Gambhir University of California Los Angeles Telephone: (310) 206-1798
12:00	Invited Presentation #4: Recent Advances in Small Animal PET (Green) Mike Green National Institutes of Health Telephone: (301) 496-5675
12:20	Invited Presentation #5: Dual-Modality of Structure and Function in Small Animals (Hasegawa) Bruce Hasegawa University of California San Francisco Telephone: (415) 502-4494
12:40 - 1:30 Lunch Break
1:30 - 3:30 New Developments in Small Animal Imaging Technology 1 (Session 3) Chairs: Jerry Glickson (University of Pennsylvania), Robert Mach (Wake Forest)
1:30	137	Chatziioannou	Fast Dynamic Whole Body Imaging of Mice with a Dedicated High Resolution PET Scanner: microPET P4
1:50	154	Streif	In Vivo Time-resolved Quantitative Motion Mapping of the Myocardium of Mice with Phase-contrast Cine-MRI
2:10	133	Nahrendorf	In Vivo Assessment of Rat Hearts with and without Myocardial Infarction by Cine NMR- comparison of the NMR Method to Invasive Techniques and Application to Intervention Studies
2:30	186	Williams	Prototype CT-SPECT Scanner for Small Animal Imaging
2:50	202	Miyaoka	Design and Performance Characteristics of High Resolution Detectors for Small Animal PET: MiCE2 and cMiCE
3:10	106	Goertzen	Design of a Simultaneous Combined PET-CT Imaging System for Mouse Imaging
3:30 - 3:50 Afternoon Break
3:50 - 5:30 New Developments in Small Animal Imaging Technology 2 (Session 4) Chairs: Steven Meikle (Royal Prince Alfred Hospital, Sydney), Ralph Weissleder (Harvard/MGH)
3:50	177	Vaquero	The NIH ATLAS Small Animal PET Scanner
4:10	198	Chen	Small Animal Imaging using a Clinical 1.5T MR Imager with a High-strength Gradient Coil Insert
4:30	230	Gleason	Probabilistic Shape and Appearance Model for the Segmentation of Anatomic Structures within Tomographic Images of Laboratory Mice
4:50	195	Ford	Fundamental Limits to Precision in Small Animal Computed Tomography
5:10	150	Morris	Methods for Multi-sample Imaging: Strategies and Applications of Mouse Phenotyping via MRI
5:30- 9:30 Poster Session and NIH Animal Imaging Center Tour (Session 5)

8:00 - 10:00 New Developments in Small Animal Imaging Technology 3 (Session 6) Chairs: Bruce Hasegawa (UC San Francisco), Richard Carson (NIH)

8:00

207

Rubins
An Automated Atlas-based Image Analysis System for Quantitative PET Studies of the Rat Brain

8:20

226

Shi
High-throughput Phenotypic Screening of Mutant Mice Using High Resolution Computed Tomography

8:40

146

Ritman
Cryostatic, Three-dimensional Micro-CT Imaging of Tissue Specimens

9:00

143

McElroy
Ultra-high Resolution In Vivo I-125 and Tc-99m Small Animal Pinhole SPECT Imaging

9:20

214

Meikle
Development of a Coded Aperture Detector for High Sensitivity, High Resolution SPECT Imaging of Laboratory Animals

9:40

193

Krishna
Non-invasively Mapping pO2 in Tumor Bearing Mice using Overhauser Enhanced Magnetic Resonance Imaging

10:00 - 10:20 Morning Break

10:20 - 12:30 Cancer and Gene Expression Imaging (Session 7) Chairs: Martin Pomper (Johns Hopkins), Sam Gambhir (UCLA)

10:20

126

McCarthy
In Vivo Imaging of Adoptive Immunotherapy: the CMS5/DUC18 Tumor Ablation Model

10:40

160

Walter
Noninvasive Monitoring of Myoblast Transfer for the Treatment of Muscular Distrophies

11:00

167

Bulte
Cellular Imaging: High Resolution MR Tracking of Magnetically Labeled Cells Following Transplantation

11:20

217

Soghomonyan
Multi Modality Brain Imaging in Rat Model

11:40

130

Lewis
MRI and microPET Imaging of Tumor Progression in Hamster Abdomens Following Laparoscopic Surgery and Radiotherapy

12:00

129

Oyama
MicroPET Assessment of Androgenic Control of Glucose and Acetate Metabolism in Prostate Cancer Tumor Model

12:20

221

Weber
Workshop Report: Standardization of Performance Measurements of Dedicated High Resolution Positron Emission Tomographs

12:30 - 1:30 Lunch Break

1:30 - 3:25 Small Animal Handling Program I (Session 8) Chairs: John Hoffman (NIH),
Dan Turnbull (Skirball Institute, New York University)

1:30 - 2:30

Hedlund
Keynote: Great Images from Creatures Small and Smaller: Biological Technologies Enabling High Resolution In Vivo Imaging

Laurence W. Hedlund
Duke University
Telephone: (919) 684-7767

2:30 - 2:45

Hedlund
Keynote Question /Answer Session

2:45 - 3:05

Cherry
PET/SPECT Imaging and Issues

Simon Cherry
University of California Davis
Telephone: (310) 825-4334

3:05 - 3:25

Paulus
CT Imaging and Issues

Michael Paulus
Oak Ridge National Laboratory
Telephone: 865-241-4802

3:25 - 3:50 Afternoon Break

3:50 - 5:30 Small Animal Handling Program II (Session 9) Chairs: John Hoffman (NIH),
Dan Turnbull (Skirball Institute, New York University)

3:50 - 4:10

Rudin
MRI in Drug Research: From the Structure to the Target

Markus Rudin
Novartis Pharma Ltd

4:10 - 4:30

Turnbull
US Imaging and Issues

Daniel Turnbull
New York University
Telephone: (212) 263-7262

4:30 - 4:50

Contag
Ani

Christopher Contag
Stanford University
Telephone: (650) 725-8781

mal Handling in In Vivo Bioluminescent Imaging Strategies

4:50 - 5:30

-panel-
Question /Answer Session

Evening: Dinner Cruise - Speaker: Barbara Croft

8:00 - 10:00 Central Nervous System / Cardiovascular Imaging (Session 10) Chairs: Alan Koretsky (NIH), Timothy McCarthy (Washington University, St. Louis)

8:00

162

Brownell
Glucose Utilization Assessed by High Resolution PET with Comparison to MRI/MRS in a Transgenic Mouse Model of Huntington's Disease

8:20

158

Song
Detection of White Matter Tracts in Mouse Brain and Spinal Cord using MR DTI

8:40

213

Berr
Magnetic Resonance Imaging of Myocardial Ischemia and Reperfusion in Mice

9:00

179

Francis
Whole Body Bioluminescent Imaging for the Study of Animal Models of Human Microbial Disease

9:20

191

Moerlein
High Resolution Imaging of Neuroreceptor Activity in Living Rodents using MicroPET

9:40

227

Liu
Quantitative Analysis of Acute Myocardial Infarction in Rats Using a High Resolution Stationary SPECT System

10:00 - 10:20 Morning Break

10:20 - 12:30 New Developments in Small Animal Imaging Technology 4 (Session 11) Chairs: Mark Williams (University of Virginia), Brian Rutt (Robarts Research Institute, Ontario)

10:20

149

Chance
3D Imaging of Intrinsic and Extrinsic Probes of Subsurface Tumors in Animal Models of Breast, Prostate and Brain

10:40

220

Ntziachristos
Fluorescence-mediated Molecular Tomography

11:00

140

Turnbull
Transplantation of Neural Stem Cells in the Mouse Brain: Ultrasound and Magnetic Resonance Micro-imaging Studies

11:20

215

Foster
A New High Frequency Ultrasound Biomicroscope for the Mouse

11:40

139

Charnsangavej
High Resolution Functional CT in Quantification of Antiangiogenic Therapy: A Preliminary Study in Animal Model

12:00

116

Rice
High-sensitivity Imaging System for In Vivo Detection of Light Emitting Reporters

12:20 - 1:00 Lunch Break

1:00 - 2:50 Small Animal Handling Program III (Session 12) Chairs: Barbara Croft (NIH),
Al Johnson (Duke University)

1:00 - 1:40

White
Reconciling Animal Health and Housing with Imaging Techniques

William White
Charles River Labs
Telephone: (508) 658-6000, Ext. 1347

1:40 - 2:20

Lukasik
Animal Preparation, Anesthesia, Body Temperature Maintenance, Physiologic Monitoring

Victoria Lukasik
University of Arizona

2:20 - 2:50

-panel-
Question /Answer Session (Contag, Johnson, Lukasik, Turnbull, White)

2:50 - 3:20 Afternoon Break

3:20 - 5:30 Small Animal Handling Program IV (Session 13) Chairs: Barbara Croft (NIH),
Al Johnson (Duke University)

3:20 - 3:50

Zhong
Microsurgical Techniques

Robert Zhong
University of Western Ontario

3:50 - 4:20

Maronpot
Pathology Correlations and Issues

Robert Maronpot
National Institutes of Health
Telephone: (919) 541-4861

4:20 - 4:50

Smith
Acute and Chronic Vascular Access in the Small Rodent

Thomas Smith
Wake Forest University

4:50 - 5:00

Sharp
Imager’s Perspective

Terry Sharp
Washington University

5:00 - 5:30

-panel-

Question /Answer Session (Cherry, Maronpot, Paulus, Sharp, Smith, Zhong)

8:00 - 10:00 New Developments in Small Animal Imaging Technology 3 (Session 6) Chairs: Bruce Hasegawa (UC San Francisco), Richard Carson (NIH)
8:00	207	Rubins	An Automated Atlas-based Image Analysis System for Quantitative PET Studies of the Rat Brain
8:20	226	Shi	High-throughput Phenotypic Screening of Mutant Mice Using High Resolution Computed Tomography
8:40	146	Ritman	Cryostatic, Three-dimensional Micro-CT Imaging of Tissue Specimens
9:00	143	McElroy	Ultra-high Resolution In Vivo I-125 and Tc-99m Small Animal Pinhole SPECT Imaging
9:20	214	Meikle	Development of a Coded Aperture Detector for High Sensitivity, High Resolution SPECT Imaging of Laboratory Animals
9:40	193	Krishna	Non-invasively Mapping pO2 in Tumor Bearing Mice using Overhauser Enhanced Magnetic Resonance Imaging
10:00 - 10:20 Morning Break
10:20 - 12:30 Cancer and Gene Expression Imaging (Session 7) Chairs: Martin Pomper (Johns Hopkins), Sam Gambhir (UCLA)
10:20	126	McCarthy	In Vivo Imaging of Adoptive Immunotherapy: the CMS5/DUC18 Tumor Ablation Model
10:40	160	Walter	Noninvasive Monitoring of Myoblast Transfer for the Treatment of Muscular Distrophies
11:00	167	Bulte	Cellular Imaging: High Resolution MR Tracking of Magnetically Labeled Cells Following Transplantation
11:20	217	Soghomonyan	Multi Modality Brain Imaging in Rat Model
11:40	130	Lewis	MRI and microPET Imaging of Tumor Progression in Hamster Abdomens Following Laparoscopic Surgery and Radiotherapy
12:00	129	Oyama	MicroPET Assessment of Androgenic Control of Glucose and Acetate Metabolism in Prostate Cancer Tumor Model
12:20	221	Weber	Workshop Report: Standardization of Performance Measurements of Dedicated High Resolution Positron Emission Tomographs
12:30 - 1:30 Lunch Break
1:30 - 3:25 Small Animal Handling Program I (Session 8) Chairs: John Hoffman (NIH), Dan Turnbull (Skirball Institute, New York University)
1:30 - 2:30		Hedlund	Keynote: Great Images from Creatures Small and Smaller: Biological Technologies Enabling High Resolution In Vivo Imaging Laurence W. Hedlund Duke University Telephone: (919) 684-7767
2:30 - 2:45		Hedlund	Keynote Question /Answer Session
2:45 - 3:05		Cherry	PET/SPECT Imaging and Issues Simon Cherry University of California Davis Telephone: (310) 825-4334
3:05 - 3:25		Paulus	CT Imaging and Issues Michael Paulus Oak Ridge National Laboratory Telephone: 865-241-4802
3:25 - 3:50 Afternoon Break
3:50 - 5:30 Small Animal Handling Program II (Session 9) Chairs: John Hoffman (NIH), Dan Turnbull (Skirball Institute, New York University)
3:50 - 4:10		Rudin	MRI in Drug Research: From the Structure to the Target Markus Rudin Novartis Pharma Ltd
4:10 - 4:30		Turnbull	US Imaging and Issues Daniel Turnbull New York University Telephone: (212) 263-7262
4:30 - 4:50		Contag	Ani Christopher Contag Stanford University Telephone: (650) 725-8781 mal Handling in In Vivo Bioluminescent Imaging Strategies
4:50 - 5:30		-panel-	Question /Answer Session
Evening: Dinner Cruise - Speaker: Barbara Croft

8:00 - 10:00 Central Nervous System / Cardiovascular Imaging (Session 10) Chairs: Alan Koretsky (NIH), Timothy McCarthy (Washington University, St. Louis)
8:00	162	Brownell	Glucose Utilization Assessed by High Resolution PET with Comparison to MRI/MRS in a Transgenic Mouse Model of Huntington's Disease
8:20	158	Song	Detection of White Matter Tracts in Mouse Brain and Spinal Cord using MR DTI
8:40	213	Berr	Magnetic Resonance Imaging of Myocardial Ischemia and Reperfusion in Mice
9:00	179	Francis	Whole Body Bioluminescent Imaging for the Study of Animal Models of Human Microbial Disease
9:20	191	Moerlein	High Resolution Imaging of Neuroreceptor Activity in Living Rodents using MicroPET
9:40	227	Liu	Quantitative Analysis of Acute Myocardial Infarction in Rats Using a High Resolution Stationary SPECT System
10:00 - 10:20 Morning Break
10:20 - 12:30 New Developments in Small Animal Imaging Technology 4 (Session 11) Chairs: Mark Williams (University of Virginia), Brian Rutt (Robarts Research Institute, Ontario)
10:20	149	Chance	3D Imaging of Intrinsic and Extrinsic Probes of Subsurface Tumors in Animal Models of Breast, Prostate and Brain
10:40	220	Ntziachristos	Fluorescence-mediated Molecular Tomography
11:00	140	Turnbull	Transplantation of Neural Stem Cells in the Mouse Brain: Ultrasound and Magnetic Resonance Micro-imaging Studies
11:20	215	Foster	A New High Frequency Ultrasound Biomicroscope for the Mouse
11:40	139	Charnsangavej	High Resolution Functional CT in Quantification of Antiangiogenic Therapy: A Preliminary Study in Animal Model
12:00	116	Rice	High-sensitivity Imaging System for In Vivo Detection of Light Emitting Reporters
12:20 - 1:00 Lunch Break
1:00 - 2:50 Small Animal Handling Program III (Session 12) Chairs: Barbara Croft (NIH), Al Johnson (Duke University)
1:00 - 1:40		White	Reconciling Animal Health and Housing with Imaging Techniques William White Charles River Labs Telephone: (508) 658-6000, Ext. 1347
1:40 - 2:20		Lukasik	Animal Preparation, Anesthesia, Body Temperature Maintenance, Physiologic Monitoring Victoria Lukasik University of Arizona
2:20 - 2:50		-panel-	Question /Answer Session (Contag, Johnson, Lukasik, Turnbull, White)
2:50 - 3:20 Afternoon Break
3:20 - 5:30 Small Animal Handling Program IV (Session 13) Chairs: Barbara Croft (NIH), Al Johnson (Duke University)
3:20 - 3:50		Zhong	Microsurgical Techniques Robert Zhong University of Western Ontario
3:50 - 4:20		Maronpot	Pathology Correlations and Issues Robert Maronpot National Institutes of Health Telephone: (919) 541-4861
4:20 - 4:50		Smith	Acute and Chronic Vascular Access in the Small Rodent Thomas Smith Wake Forest University
4:50 - 5:00		Sharp	Imager’s Perspective Terry Sharp Washington University
5:00 - 5:30		-panel-	Question /Answer Session (Cherry, Maronpot, Paulus, Sharp, Smith, Zhong)